Clinical trial Recruiting at 1 site Interventional Ages 18 to 45 Women only

Kaia Relief - Cycle System for Premenstrual Symptoms in Premenopausal Women

Official title: A Clinical Trial to Evaluate the Effects of the Kaia Relief - Cycle System on Premenstrual Symptom Severity, Menstrual Discomfort, and Overall Well-Being in Premenopausal Women

Run by Vivance Group · NCT07876050 · Data updated 2026-11-12

This trial tests whether the Kaia Relief - Cycle System can help reduce premenstrual symptoms and menstrual discomfort in healthy women aged 18–45 over about 12 weeks.

More Premenstrual Syndrome trials

Quick facts

Study typeInterventional
Ages18 Years to 45 Years
SexWomen only
Enrollment45 (estimated)
SponsorVivance Group
Industry-sponsored
Locations1 site (Las Vegas, Nevada)
StatusRecruiting
StartedOctober 2026
Main results expectedJanuary 2027
Study endsJanuary 2027
Registry record updatedOctober 15, 2026
Trial IDNCT07876050 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are women aged 18–45 with regular 24–35 day cycles and self-reported moderate, recurrent premenstrual symptoms.

Probably not a fit

Individuals who do not experience symptom improvement or who have contraindications to the product may not experience benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an open-label, single-group study conducted remotely to see if the Kaia Relief - Cycle System can lessen premenstrual symptom severity and improve overall well-being. Participants will go through a baseline cycle with no product, followed by two cycles of daily Day and Night capsule use starting seven days before the expected period, with questionnaires completed on Day 5 of each cycle. The study uses a digital platform to collect data across three cycles, focusing on changes in symptom scores and quality of life. Forty-five premenopausal women with regular cycles will participate, under remote supervision and with periodic assessments.

Why it matters

Potential benefit: Participants may experience reduced premenstrual symptoms and improved daily functioning during their cycles.

How similar studies have gone: There is limited published data on this specific product; prior work in similar dietary-supplement approaches for PMS has shown mixed outcomes.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Female sex assigned at birth and currently premenopausal.
* Aged 18 to 45 years (inclusive) at the time of informed consent.
* Regular menstrual cycles with a cycle length of 24-35 days for at least the three months prior to enrollment.
* Self-reported recurrent premenstrual symptoms (physical and/or mood) that the participant confirms resolve within a few days of menses onset, occurring in the majority of cycles over the past three months.
* Self-reported premenstrual symptoms of at least moderate severity, defined as symptoms the participant describes as bothersome enough to interfere with normal daily activities, in the majority of cycles over the past three months.
* Willing and able to take the study product every day across the two product cycles (Cycles 2 and 3) and to complete questionnaires across all three cycles.
* Willing to maintain current diet, physical activity level, sleep routine, and stable use of any ongoing supplements for the duration of the study.
* Willing to refrain from taking any new products, medications, or supplements that target menstrual health during the study period.
* Access to a smartphone, tablet, or computer with reliable internet access to complete study assessments via the digital platform.
* Resides in the United States and willing to provide a shipping address for product delivery.
* Willing and able to provide written electronic informed consent prior to any study procedures.

Exclusion Criteria:

* Pregnant, breastfeeding, trying to conceive, or planning to become pregnant during the study period.
* Peri-menopausal or post-menopausal status (self-report or known clinical diagnosis).
* Started, stopped, or changed hormonal birth control (including oral contraceptives, hormonal IUD, patch, ring, or injectable hormonal contraceptives) within the three months prior to enrollment, or planning to change hormonal contraception during the study.
* Known allergy or sensitivity to any ingredient in the study product, including allergy to plants of the Asteraceae/Compositae family (e.g., ragweed, chrysanthemum, marigold, yarrow) or to lavender or sweet orange essential oils.
* Diagnosed reproductive condition currently under active pharmacological treatment (e.g., polycystic ovary syndrome \[PCOS\], endometriosis, uterine fibroids) where treatment may confound premenstrual symptom assessment.
* Diagnosed premenstrual dysphoric disorder (PMDD) currently requiring pharmacotherapy.
* Use of SSRIs, SNRIs, or any hormonal treatment specifically prescribed or initiated for PMS or mood regulation within the three months prior to enrollment.
* Current use of hormonal contraceptives (such as the pill, patch, vaginal ring, or hormonal IUD) or any form of hormone therapy.
* Current use of dopaminergic medications (e.g., medications prescribed for Parkinson's disease, restless legs syndrome, or hyperprolactinemia), which may interact with Vitex agnus-castus.
* Current use of anticoagulant or antiplatelet medication (e.g., warfarin, heparin, clopidogrel, or prescription-dose aspirin), due to the theoretical mild antiplatelet properties of turmeric and ginger.
* Use of other dietary supplements, herbal remedies, or over-the-counter products known to influence mood, hormonal balance, water retention, or premenstrual symptoms (e.g., evening primrose oil, St.
* John's Wort, Vitex, other agnus-castus-containing products) unless used at a stable dose for at least three months prior to enrollment and the participant agrees to maintain the same routine throughout the study.
* History of serious illness, major surgery, or hospitalization within the three months prior to enrollment.
* Planned surgery, medical procedure, or significant health intervention during the study period.
* Currently enrolled in another clinical research study, or having participated in another study within the past 30 days prior to enrollment.

Where it's running

  • Citruslabs
    Las Vegas, Nevada, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.