iPACK with Adductor Canal Block for knee OA surgery: does it lower inflammatory markers after hip arthroplasty?
Official title: iPACK Block With Adductor Canal Block Mitigates Surgical Stress and Enhances Analgesia in Total Knee Arthroplasty: A Randomized Controlled Trial
Run by Poznan University of Medical Sciences · NCT07449442 · Data updated 2026-11-12
In older adults undergoing hip surgery with spinal anesthesia, this study tests whether adding an iPACK block with an Adductor Canal Block can reduce a combined inflammatory-immune score (SII) compared with a sham block.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 65 Years to 100 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Poznan University of Medical Sciences Academic / other |
| Locations | 1 site (Poznan) |
| Status | Recruiting |
| Started | March 1, 2026 |
| Main results expected | November 30, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT07449442 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Candidates are adults aged 65–100 with ASA I–III scheduled for hip arthroplasty under spinal anesthesia who can consent and do not have exclusion criteria.
✕Probably not a fit
Patients with contraindications to regional blocks, dementia, ongoing infection at the procedure site, or those undergoing general anesthesia may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial investigates whether ultrasound-guided iPACK block plus Adductor Canal Block can blunt the systemic inflammatory response to hip arthroplasty. SII, calculated from platelets, neutrophils, and lymphocytes, serves as a composite marker of inflammation and immune status. The study compares active regional anesthesia against a sham procedure in elderly adults (65–100) with ASA I–III undergoing spinal anesthesia for hip replacement. Hematologic data and perioperative recovery metrics are used to assess the intervention’s impact. The approach builds on the idea that regional anesthesia may reduce surgical stress and inflammatory activation.
Why it matters
Potential benefit: If successful, patients may experience a reduced perioperative inflammatory response, potentially aiding recovery and lowering complication risk.
How similar studies have gone: Previous work suggests regional blocks can modulate surgical stress, but direct effects on SII with iPACK and ACB in hip arthroplasty are not well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with ASA classification I-III * Aged 65-100 years * Who will be scheduled for hip arthroplasty under spinal anesthesia Exclusion Criteria: * Patients who have a history of bleeding diathesis * Take anticoagulant therapy * History of chronic pain before surgery * Multiple trauma * patients unable to assess their pain (dementia) * patients operated under general anesthesia * patients having an infection in the region of the procedure * the patient who does not accept the procedure
Where it's running
-
Poznan University of Medical Sciences
Poznan, Poland Recruiting
Study contacts
- Study coordinator: Malgorzata Reysner, MD PhD
- Email: mreysner@ump.edu.pl
- Phone: +48 501 056 924
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.