Investigation of eye infections using advanced sequencing techniques
Ocular Pathogen and Transcriptome Investigation Using Comprehensive Sequencing
This study tests if a new advanced eye infection test can help patients get the right treatment and feel better compared to standard testing methods.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of California, San Francisco Academic / other |
| Locations | 1 site (San Francisco, California) |
| Trial ID | NCT05286203 on ClinicalTrials.gov |
What this trial studies
This clinical trial compares the effectiveness of metagenomic deep sequencing (MDS) against standard care testing for patients with presumed intraocular infections. Participants will be randomly assigned to either receive MDS results or not, while all will undergo standard testing to inform their treatment. The study aims to evaluate the proportion of patients receiving appropriate therapy and those experiencing improved outcomes. Follow-up assessments will occur at specified intervals to gather data on patient quality of life and treatment efficacy.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with presumed infectious uveitis or post-operative endophthalmitis.
Not a fit: Patients under 18, pregnant individuals, or those unable to provide consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses and improved treatment outcomes for patients with intraocular infections.
How similar studies have performed: Other studies utilizing metagenomic sequencing have shown promise in improving diagnostic accuracy, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Presumed infectious anterior uveitis, or intermediate uveitis, or posterior uveitis, or panuveitis * Presumed post-operative endophthalmitis * Unilateral or bilateral * 18 years and older Exclusion Criteria: * Insufficient specimen for MDS * Age \< 18 years of age * Pregnancy * Unable to consent
Where this trial is running
San Francisco, California
- University of California San Francisco (UCSF) — San Francisco, California, United States (Recruiting)
Study contacts
- Principal investigator: Thuy Doan, MD, PhD — University of California, San Francisco
- Study coordinator: Jessica Shantha, MD
- Email: Jessica.shantha@ucsf.edu
- Phone: (415) 476-1442
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.