Investigating Troponin T Fragmentation in Heart Injury
Official title: Troponin T Fragmentation in the Assessment of Myocardial Injury Study
Run by University of Turku · NCT04465591 · Data updated 2026-11-12
This study looks at how Troponin T fragments in people who have had a heart attack or heart injury to see if it can help doctors better diagnose and manage these conditions.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1500 (estimated) |
| Sponsor | University of Turku Academic / other |
| Locations | 2 sites (Turku, Southwest Finland and 1 other locations) |
| Status | Recruiting |
| Started | April 2, 2020 |
| Main results expected | December 30, 2028 |
| Study ends | December 31, 2028 |
| Registry record updated | May 8, 2026 |
| Trial ID | NCT04465591 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients who have had a Troponin T fragmentation sample collected and are experiencing acute myocardial infarction or myocardial injury.
✕Probably not a fit
Patients under 18 years of age will not be eligible for this study and therefore will not benefit from its findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the fragmentation of Troponin T (TnT) in patients with acute myocardial infarction and myocardial injury. It will analyze the prevalence of TnT fragmentation across different patient cohorts, particularly in those with conditions that may elevate TnT levels, such as chronic kidney disease or following physical exercise. The study seeks to clarify the clinical significance of TnT fragmentation and its implications for diagnosing myocardial injury. By understanding these mechanisms, the research hopes to improve diagnostic accuracy and patient management in acute coronary syndromes.
Why it matters
Potential benefit: If successful, this study could enhance the diagnostic accuracy for myocardial injury, reducing unnecessary procedures and improving patient outcomes.
How similar studies have gone: While the fragmentation of Troponin T is a relatively novel area of investigation, previous studies have indicated potential benefits in understanding troponin dynamics, suggesting that this approach may yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Troponin T fragmentation sample collected from a recruited patient. Exclusion Criteria: * Age \<18
Where it's running
-
Turku University Hospital, Heart Center
Turku, Southwest Finland, Finland Recruiting -
University Hospital Zurich
Zurich, Switzerland Enrolling by invitation
Study contacts
- Principal investigator: Juhani K Airaksinen, MD, PhD — University of Turku
- Study coordinator: Juhani K Airaksinen, MD, PhD
- Email: juhani.airaksinen@tyks.fi
- Phone: +358 2 3131005
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.