Ciprofol to reduce heart injury after VATS lung surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 45–80 scheduled for elective video-assisted thoracoscopic lung or mediastinal surgery receive general anesthesia with either ciprofol or propofol and are monitored during and after surgery. The study tracks postoperative cardiac troponin levels to identify myocardial injury (MINS), along with perioperative hemodynamics and clinical outcomes. Key exclusions include known allergy to study drugs, unstable angina or heart failure needing vasopressors, severe COPD, severe renal or hepatic dysfunction, and pregnancy or lactation. The trial is conducted at Tongji Hospital in Wuhan with participants expected to remain hospitalized for at least three days for postoperative monitoring.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Scheduled for elective video-assisted thoracoscopic (VATS)-assisted thoracic surgery (lobectomy, segmentectomy, wedge resection of two or more lung tissues, mediastinal tumor resection) under general anesthesia;
2. Aged 45 to 80 years (inclusive) at the time of randomization;
3. Expected postoperative hospital stay of ≥3 days;
4. Signed a written informed consent to participate in the study.

Exclusion Criteria:

1. Patients allergic to propofol, Ciprofol, or analogs of drug excipient components (soybeans, eggs, milk);
2. Patients with unstable angina;
3. Patients with congestive heart failure or hemodynamic instability requiring vasopressor agents;
4. Patients with severe COPD (FEV1 \< 1 L);
5. Glomerular filtration rate \[eGFR\] \< 30 mL/min/1.73m²;
6. Patients with severe hepatic dysfunction (ALT or AST elevation exceeding 1.5 times the upper limit of normal);
7. Male or female patients planning to conceive within the next 3 months;
8. Pregnant or lactating female patients;

Where it's running

• Tongji hospital
  Wuhan, China Recruiting

Study contacts

• Study coordinator: Ailin Luo, MD&PhD
• Email: alluo@tjh.tjmu.edu.cn
• Phone: 13507122565

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Understanding heart artery disease using biomarkers and imaging in Oxford

  Researchers in Oxford are testing how biomarkers and advanced imaging can help explain why some heart artery plaques are unstable and how this affects heart damage after a heart attack.

  Recruiting University of Oxford · Oxford · NCT07772570

• AI-assisted chest CT report drafting to save radiologist time

  This study tests whether an AI draft report can help experienced chest radiologists write chest CT reports faster without sacrificing quality.

  Recruiting at 2 sites Shanghai Zhongshan Hospital · Shanghai and 1 other locations · NCT07634861

• Manual chest wall vibration to help breathing and remove chest tubes after thoracic surgery

  This trial tests whether manual vibration of the chest wall helps clear secretions and shortens chest tube time for people recovering from thoracic surgery.

  Recruiting Saglik Bilimleri Universitesi · Istanbul · NCT07549555

• Video-guided right-sided double-lumen tube for one-lung ventilation in thoracoscopic surgery

  This trial tests whether a video-guided right-sided double-lumen tube helps place and use the tube during thoracoscopic surgery requiring one-lung ventilation, compared with a conventional tube.

  Recruiting at 2 sites Zhejiang University · Hangzhou, Zhejiang and 2 other locations · NCT07362797

• Perioperative high-dose nicotine patch for pain sensitivity in male smokers undergoing thoracic surgery

  We will try a high-dose nicotine patch around the time of surgery to see if it reduces pain sensitivity in adult male smokers having thoracoscopic lung surgery.

  Recruiting Henan Provincial People's Hospital · Zhengzhou, Henan · NCT07250230

• Predicting heart transplant outcomes using donor heart biopsies

  This study is testing if looking at tissue samples from donor hearts can help predict how well the transplanted hearts will work and if they'll be rejected by the recipient's body.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT06982404

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.