Investigating the link between muscle loss and rocuronium use in liver transplant patients
Association of Sarcopenia With Rocuronium Use in Liver Transplant Recipients
NA · Inonu University · NCT06909942
This study is trying to see how muscle loss affects the use of a specific anesthesia drug in liver transplant patients aged 18-65.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 3 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Inonu University (other) |
| Locations | 1 site (Malatya, Battalgazi) |
| Trial ID | NCT06909942 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore how sarcopenia affects the use of rocuronium in patients scheduled for liver transplantation. It will assess sarcopenia through a three-stage algorithm that includes the SARC-F questionnaire, hand grip strength measurement, and the Psoas Muscle Index calculated from preoperative CT images. The study will involve patients aged 18-65 with ASA II-III classifications, who will undergo routine monitoring and anesthesia protocols during their liver transplant surgery. Data on patient characteristics and preoperative health metrics will be collected to analyze the relationship between muscle mass and anesthetic requirements.
Who should consider this trial
Good fit: Ideal candidates are liver transplant recipients aged 18-65 with ASA II-III classifications.
Not a fit: Patients under 18, over 65, or with severe comorbidities such as advanced renal failure or heart failure may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved anesthetic management and outcomes for liver transplant recipients with sarcopenia.
How similar studies have performed: While studies on sarcopenia in surgical patients exist, this specific investigation into its impact on rocuronium use in liver transplant recipients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with American Society of Anesthesiologists (ASA) 2-3, * Patients over the age of 18, * Liver transplant recipient candidates who have agreed to receive an organ transplant Exclusion Criteria: * Patients who are unconscious enough to not be included in the study (patients for whom consent cannot be obtained and the study cannot be explained) * Patients under the age of 18 * Patients aged 65 and over * Patients with advanced renal failure * Patients with massive ascites in the abdomen * Patients with advanced heart failure or high pulmonary artery pressure for whom routine anesthesia induction protocols must be excluded * Patients with psychosis or substance abuse Patients with a known adverse reaction to rocuronium * Patients with indications for rapid sequence intubation
Where this trial is running
Malatya, Battalgazi
- Turgut Ozal Medicine Center Liver Transplantation Institute — Malatya, Battalgazi, Turkey (RECRUITING)
Study contacts
- Study coordinator: Emre Arıkan, assistant doctor
- Email: arikanemre00@gmail.com
- Phone: +905535822001
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Sarcopenia, Sarcopenia in Liver Cirrhosis, Liver Transplantation, sarcopenia, psoas muscle index, handgrip dynamometer, liver transplantation