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Clinical trial No longer in our active list Observational Ages 18 and up

Investigating the link between immune thrombocytopenia and cancer

Official title: Molecular Analysis of Thrombocytopenia and Cancer (MATAC): Investigating Antigenic Mimicry Between Platelets and Tumor Cells in Patients With Immune Thrombocytopenia (ITP) Associated With Cancer

Run by University Hospital, Bordeaux · NCT06444477 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study looks at whether having immune thrombocytopenia (ITP) is linked to cancer and if cancer cells might cause the body to attack its own platelets.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment70 (estimated)
SponsorUniversity Hospital, Bordeaux
Academic / other
Locations20 sites (Bondy and 19 other locations)
Trial IDNCT06444477 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adult patients who have been diagnosed with both immune thrombocytopenia and cancer, with the onset of ITP occurring within six months of the cancer diagnosis.

Probably not a fit

Patients who do not have a diagnosis of both ITP and cancer will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between immune thrombocytopenia (ITP) and various cancers, particularly focusing on the hypothesis that tumor cells may trigger an autoimmune response against platelets. By collecting retrospective data from multiple centers, the study will analyze patient demographics, treatment histories, and outcomes related to both ITP and cancer. The goal is to better understand how chronic expression of certain proteins by tumor cells could lead to the development and persistence of ITP in cancer patients.

Why it matters

Potential benefit: If successful, this study could provide insights that lead to improved management and treatment strategies for patients suffering from ITP associated with cancer.

How similar studies have gone: While the association between ITP and hematologic malignancies is well-documented, the exploration of this link with solid tumors is less established, making this study a novel investigation.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Adult patients with a definite diagnosis of both ITP and cancer;
* Synchronous diagnosis of ITP and cancer;
* Onset of ITP occurring 6 months before or after the diagnosis of cancer.

Exclusion Criteria:

* None

Where it's running

  • AP-HP Hôpital Jean Verdier service de médecine interne
    Bondy, France     Recruiting
  • CHU de Clermont-Ferrand - service de médecine interne
    Clermont-Ferrand, France     Recruiting
  • AP-HP Hôpital Mondor service de médecine interne
    Créteil, France     Recruiting
  • AP-HP Hôpital Bicêtre service de médecine interne
    Le Kremlin-Bicêtre, France     Recruiting
  • AP-HM Hôpital la Timone - service de médecine interne
    Marseille, France     Recruiting
  • CHRU de Nancy - service de Médecine Interne et Immunologie Clinique
    Nancy, France     Recruiting
Show 14 more locations
  • AP-HP Hôpital Saint-Louis service immuno-hématologie
    Paris, France     Recruiting
  • CHU de Bordeaux Service de Médecine Interne et Maladies Infectieuses
    Pessac, France     Recruiting
  • CHU de Poitiers - service de médecine interne
    Poitiers, France     Recruiting
  • CHU de Tours - service de médecine interne
    Tours, France     Recruiting
  • CHU de Lille - service d'Hématologie
    Lille, France     Not yet recruiting
  • HCL - service d'Hématologie
    Lyon, France     Not yet recruiting
  • CHU de Montpellier - service d'Hématologie
    Montpellier, France     Not yet recruiting
  • CHU de Nantes - service de médecine interne
    Nantes, France     Not yet recruiting
  • CHRU d'Orléans - service de Médecine interne
    Orléans, France     Not yet recruiting
  • CHRU d'Orléans - service de réanimation
    Orléans, France     Not yet recruiting
  • AP-HP Hôpital Bichat service de médecine interne
    Paris, France     Not yet recruiting
  • AP-HP Hôpital Saint-Antoine service de médecine interne
    Paris, France     Not yet recruiting
  • CHRU de Strasbourg - service de médecine interne
    Strasbourg, France     Not yet recruiting
  • CHU de Toulouse - service de médecine interne
    Toulouse, France     Not yet recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.