Investigating the genetics of appendix cancer
Genetics of Appendix Cancer: The GAP Study
This study is trying to find out how genetics might play a role in appendix cancer by following adults with the disease for up to six years.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 700 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Vanderbilt-Ingram Cancer Center Academic / other |
| Locations | 1 site (Nashville, Tennessee) |
| Trial ID | NCT05734430 on ClinicalTrials.gov |
What this trial studies
The Genetics of Appendix Cancer (GAP) Study is a prospective cohort study that aims to explore genetic variations linked to appendix cancer in adults aged 18 and older. Participants diagnosed with appendix cancer will be recruited and followed for up to six years, during which their hereditary factors, tumor characteristics, and clinical outcomes will be analyzed. The study will also involve collecting biospecimens and comprehensive data to enhance understanding of this rare cancer type.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with a confirmed diagnosis of appendix cancer in the United States.
Not a fit: Patients who are pregnant, unable to provide informed consent, or do not speak English may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding of genetic factors in appendix cancer, potentially guiding personalized treatment strategies.
How similar studies have performed: While the study focuses on a rare cancer type, similar genetic studies in other cancers have shown promise in identifying hereditary factors and improving patient outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: GAP Social * Known diagnosis of appendix cancer in the United States * Mentally and physically able to consent and participate in the study GAP Vanderbilt * Known diagnosis of appendix cancer * Diagnosed by and/or consulting with a physician/clinical provider participating in the GAP Study * Mentally and physically able to consent and participate in the study GAP Parent * Biological parents (mother and/or father) of individuals actively participating in the GAP Study * Residing in the United States * Mentally and physically able to consent and participate in the study Exclusion Criteria: * Women pregnant at the time of consent * Prisoners * Unable to provide informed consent * Unable to read, write, or complete questionnaires in English
Where this trial is running
Nashville, Tennessee
- Vanderbilt-Ingram Cancer Center — Nashville, Tennessee, United States (Recruiting)
Study contacts
- Principal investigator: Andreana N Holowatyj, PhD, MSCI — Vanderbilt-Ingram Cancer Center
- Study coordinator: GAP Study Coordinator (Rebecca B.)
- Email: gapcancerstudy@vumc.org
- Phone: 615-936-8544
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.