Investigating the genetic regulation of colorectal polyps and cancer
Epigenetic Regulation of Colorectal Polyps and Cancer and Its Traceability in Blood
This study is testing how certain genetic and microbiome factors might be linked to the development of colorectal polyps and cancer in people undergoing colonoscopy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Region Skane Academic / other |
| Locations | 1 site (Malmö, Skåne) |
| Trial ID | NCT06206603 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the epigenetic and genetic factors, specifically microRNA and mRNA expressions, involved in the development of colorectal polyps and cancer. Patients undergoing colonoscopy for polyp evaluation will have biopsies taken from their polyps or cancers, as well as blood samples, to analyze the correlation between tissue and blood microRNA/mRNA expressions. Additionally, the study will assess the intestinal microbiota to determine its relationship with colorectal polyps and cancer. Healthy controls with normal colonoscopy findings will also be included for comparison.
Who should consider this trial
Good fit: Ideal candidates include patients over 18 years old who are referred for colonoscopy due to suspected colorectal polyps.
Not a fit: Patients with a history of colorectal cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and prevention strategies for colorectal cancer.
How similar studies have performed: While the study's specific approach is novel, similar studies have shown promise in understanding the role of microRNA/mRNA in cancer progression.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients over 18 years referred for colonoscopy for examination or evaluation/removal of colorectal polyps. Exclusion Criteria: * Patients with a history of colorectal cancer. * Patients not in capacity to understand the study information and give informed consent.
Where this trial is running
Malmö, Skåne
- Skane University Hospital, Malmö, section of Surgery — Malmö, Skåne, Sweden (Recruiting)
Study contacts
- Study coordinator: Carl-Fredrik Rönnow, MD, PhD
- Email: carl-fredrik.ronnow@med.lu.se
- Phone: +46768081218
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.