Investigating silent myocardial ischemia in patients undergoing abdominal surgeries
Silent Myocardial Ischemia in Patients Undergoing Non-oncological Abdominal Surgeries
This study is testing how often heart problems happen without symptoms in people having non-cancer abdominal surgeries and looking at factors like blood markers and genetics that might affect heart health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Medical Centre Ljubljana Academic / other |
| Locations | 1 site (Ljubljana) |
| Trial ID | NCT06536686 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the occurrence of silent myocardial ischemia in patients undergoing non-oncological abdominal surgeries. It focuses on measuring troponin T levels before surgery and collecting blood samples for N-terminal pro-BNP to evaluate cardiovascular risk. Additionally, the study will explore the genetic factors, particularly MTHFR gene polymorphisms, that may contribute to myocardial infarction. The research also considers the role of non-coding RNAs and extracellular vesicles in cardiovascular health during the perioperative period.
Who should consider this trial
Good fit: Ideal candidates include patients with non-oncological abdominal diseases who do not have pre-existing cardiovascular conditions.
Not a fit: Patients with active cancer, pregnant women, psychiatric patients, those with dementia, or individuals unable to understand basic instructions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved identification and management of silent myocardial ischemia, potentially reducing perioperative cardiovascular events.
How similar studies have performed: Other studies have shown success in identifying silent myocardial ischemia using similar biomarkers, indicating a promising approach in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with non-oncological abdominal disease and without cardiovascular disease * Patients with STEMI Exclusion Criteria: * Patients with active cancer * Pregnant women * Psychiatric patients * Patient with dementia * Patients who do not understand basic instructions * Alcohol and illegal drug addicts
Where this trial is running
Ljubljana
- UMC Ljubljana — Ljubljana, Slovenia (Recruiting)
Study contacts
- Principal investigator: Jasna Klen, MD, PhD — University Medical Centre Ljubljana
- Study coordinator: Jasna Klen, MD, PhD
- Email: jasna.klen@gmail.com
- Phone: 0038631510916
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.