Investigating red blood cell function in patients with end-stage renal disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on how end-stage renal disease (ESRD) affects the deformability of erythrocytes, which is crucial for effective oxygen transport. It examines the relationship between erythrocyte biomechanical properties and aerobic capacity in patients undergoing hemodialysis. The study involves blood collection and cardiopulmonary exercise testing to assess the impact of osmotic imbalances, oxidative stress, and uremic toxins on red blood cell function and microcirculation. By understanding these mechanisms, the research aims to identify potential therapeutic targets to improve vascular health in ESRD patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Receiving hemodialysis and medication at least for 6 weeks
* Kt/V score \> 1.2

Exclusion Criteria:

* Under 20 years-old
* Hyperkalemia occurs within 3 month
* Having orthopedic or muscular diseases
* Other concerned medical, psychological or physiological diseases
* Pregnancy
* Other exercise contraindications

Where it's running

• Chang Gung University
  Taoyuan, Taiwan Recruiting

Study contacts

• Study coordinator: Jong-Shyan Wang, PhD
• Email: s5492@mail.cgu.edu.tw
• Phone: +886-3-2118800 Ext. 5748

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.