Investigating red blood cell function in patients with end-stage renal disease
The Effect of Osmotic Stress in Erythrocyte Rheology in ESRD Patients
Chang Gung Memorial Hospital · NCT06868888
This study is trying to see how end-stage kidney disease affects red blood cells and their ability to carry oxygen in patients who are on dialysis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 20 Years and up |
| Sex | All |
| Sponsor | Chang Gung Memorial Hospital (other) |
| Locations | 1 site (Taoyuan) |
| Trial ID | NCT06868888 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on how end-stage renal disease (ESRD) affects the deformability of erythrocytes, which is crucial for effective oxygen transport. It examines the relationship between erythrocyte biomechanical properties and aerobic capacity in patients undergoing hemodialysis. The study involves blood collection and cardiopulmonary exercise testing to assess the impact of osmotic imbalances, oxidative stress, and uremic toxins on red blood cell function and microcirculation. By understanding these mechanisms, the research aims to identify potential therapeutic targets to improve vascular health in ESRD patients.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 20 years old who have been receiving hemodialysis for at least six weeks and have a Kt/V score greater than 1.2.
Not a fit: Patients with recent hyperkalemia, orthopedic or muscular diseases, or other significant medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for enhancing oxygen delivery and overall health in ESRD patients.
How similar studies have performed: While the specific focus on erythrocyte deformability in ESRD is novel, related studies have shown the importance of red blood cell function in various conditions, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Receiving hemodialysis and medication at least for 6 weeks * Kt/V score \> 1.2 Exclusion Criteria: * Under 20 years-old * Hyperkalemia occurs within 3 month * Having orthopedic or muscular diseases * Other concerned medical, psychological or physiological diseases * Pregnancy * Other exercise contraindications
Where this trial is running
Taoyuan
- Chang Gung University — Taoyuan, Taiwan (RECRUITING)
Study contacts
- Study coordinator: Jong-Shyan Wang, PhD
- Email: s5492@mail.cgu.edu.tw
- Phone: +886-3-2118800 Ext. 5748
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: End-stage Renal Disease, Hemodialysis, Aerobic capacity, Deformability, Erythrocyte