Investigating nerve and blood vessel growth in deep endometriosis
Pelvic Neuro-Angiogenesis Density in the Presence of Deep Endometriosis and Relationship Between Pelvic Pain Scores
This study is testing how nerve and blood vessel growth in endometriosis tissue affects pain levels in patients having surgery, to help improve surgical techniques and outcomes.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | Uludag University Academic / other |
| Locations | 1 site (Bursa, Gorukle) |
| Trial ID | NCT06286371 on ClinicalTrials.gov |
What this trial studies
This study examines the relationship between nerve and blood vessel density in excised endometriotic nodules and the pain experienced by patients undergoing laparoscopic douglasectomy surgery. It aims to correlate the presence of pain mediators with pain scores to better understand the mechanisms behind endometriosis-related pain. The findings will help define surgical excision boundaries and safe margins during surgery for endometriosis that does not respond to medical treatment.
Who should consider this trial
Good fit: Ideal candidates include women with suspected deep endometriosis who have not responded to medical therapy and are scheduled for laparoscopic conservative surgery.
Not a fit: Patients with malignancy suspicion, extensive surgical history, or previous pelvic surgeries may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved surgical techniques and pain management strategies for women suffering from deep endometriosis.
How similar studies have performed: While there have been studies on endometriosis and pain management, this specific investigation into neurovascular changes in deep endometriosis is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with suspicion of deep endometriosis (Physical Examination and MRI) * Patients with ineffective response to medical therapy * Patients who undergo laparoscopic conservative endometriosis surgery (douglasectomy) Exclusion Criteria: * Patients with malignity suspicion * Patients with extensive surgery (hysterectomy, ovariectomy) * Patients with previous endometriosis or another pelvic surgery * Patients with oocyte pick up procedure history * Patients with pelvic inflammatory disease history
Where this trial is running
Bursa, Gorukle
- Uludag University Faculty Hospital — Bursa, Gorukle, Turkey (Recruiting)
Study contacts
- Study coordinator: Kiper Aslan, Assoc. Prof.
- Email: kiperaslan@uludag.edu.tr
- Phone: +905548127272
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.