Investigating metabolic changes in patients with obesity undergoing bariatric surgery
Metabolomics and Bariatric Surgery in Patients With Metabolically Unhealthy Obesity: Advancing Precision Medicine for the Treatment of Obesity
This study looks at how bariatric surgery affects metabolic health in people with obesity to see if certain markers can help predict who will become healthier after the surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 145 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Parc de Salut Mar Academic / other |
| Locations | 1 site (Barcelona) |
| Trial ID | NCT06297928 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore metabolic changes in individuals with varying metabolic health statuses who are undergoing bariatric surgery. It will assess whether metabolic markers can predict the transition from metabolically unhealthy to healthy obesity post-surgery and examine the metabolic differences between these groups before and after the procedure. Participants will undergo routine evaluations and blood tests, including metabolomic analysis, to track changes in their metabolic profiles. The study will involve a multidisciplinary team and will not require additional visits beyond standard clinical practice.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 60 with a Body Mass Index (BMI) of 40 or greater, or 35 or greater with obesity-related comorbidities, who are undergoing bariatric surgery.
Not a fit: Patients with a history of previous bariatric surgery, severe psychiatric disorders, or contraindications for major abdominal surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help identify metabolic markers that predict health outcomes after bariatric surgery, potentially improving patient selection and treatment strategies.
How similar studies have performed: While there have been studies on metabolic changes post-bariatric surgery, this specific focus on metabolomics in relation to metabolic health status is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients undergoing bariatric surgery at the Hospital del Mar in Barcelona. Criteria for bariatric surgery are: * Ages between 18 and 60 years. * Body Mass Index (BMI) equal to or greater than 40, or equal to or greater than 35 kg/m2 with at least one obesity-related comorbidity (type 2 diabetes mellitus, hypertension, dyslipidemia, obstructive sleep apnea syndrome). * Previous failure with conventional treatment involving diet and exercise. Exclusion Criteria: * History of previous bariatric surgery. * Presence of severe psychiatric disorders, severe eating disorders, alcohol or drug abuse. * Contraindications for major abdominal surgery, active gastric ulcer, severe liver disease. Pregnancy or lactation.
Where this trial is running
Barcelona
- Hospital del Mar — Barcelona, Spain (Recruiting)
Study contacts
- Study coordinator: David Benaiges, PhD
- Email: dbenaiges@psmar.cat
- Phone: 0034932483902
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.