Investigating long-term risks and STI rates in PrEP users in France

Long-term Evolution of Risky Sexual Behaviors and Prevalence of Sexually Transmitted Infections Among Pre-Exposure Prophylaxis Users: A Retrospective Observational Study in Gironde, France

Observational University Hospital, Bordeaux · NCT06600087

This study looks at the long-term effects of PrEP on sexual behavior and STI rates in people using it in France to see how it compares between those on PrEP for over a year and those on it for less than a year.

Quick facts

Study typeObservational
Enrollment300 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity Hospital, Bordeaux Academic / other
Locations8 sites (Bordeaux and 7 other locations)
Trial IDNCT06600087 on ClinicalTrials.gov

What this trial studies

The SAFER-PrEP study examines the long-term effects of Pre-Exposure Prophylaxis (PrEP) on sexual behaviors and the prevalence of sexually transmitted infections (STIs) among users in Aquitaine, France. It compares STI rates between individuals who have been on PrEP for over a year and those who have been on it for less than a year. This observational study collects data through self-administered questionnaires during routine PrEP consultations, aiming to provide insights that could inform future PrEP prescriptions and enhance public health strategies.

Who should consider this trial

Good fit: Ideal candidates for this study are French-speaking individuals over 18 years old who have been using PrEP for at least 6 months.

Not a fit: Patients who are known to be HIV positive will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding of the long-term implications of PrEP use, ultimately enhancing HIV prevention strategies and sexual health outcomes.

How similar studies have performed: Other studies have explored the effects of PrEP on sexual health, but this specific investigation into long-term risks and STI prevalence is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Aged over 18 years old;
* Participants using PrEP for at least 6 months ;
* French-speaking, without comprehension disorders ;
* being affiliated to health insurance ;
* Willing to participate and to sign informed consent.

Exclusion Criteria:

* Individuals with known HIV positivity;

Where this trial is running

Bordeaux and 7 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions HIV InfectionsSexually Transmitted DiseasesPre-Exposure ProphylaxisHIV PreventionSexually Transmitted InfectionsLong-term EffectsBehavioral Trends
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.