Investigating kidney function during dialysis in ICU patients
Impact of Continuous Renal Replacement Therapy on Renal Oxygenation, Blood Flow and Function
This study is trying to find the best blood pressure for kidney function during dialysis in ICU patients with acute kidney injury.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Sahlgrenska University Hospital Academic / other |
| Locations | 1 site (Gothenburg) |
| Trial ID | NCT04114747 on ClinicalTrials.gov |
What this trial studies
This study examines the physiological changes in the kidneys of ICU patients suffering from acute kidney injury (AKI) when starting continuous renal replacement therapy (CRRT) at different blood pressure levels. By enrolling 20 patients, the research aims to determine the optimal blood pressure for kidney function during dialysis using a retrograde renal vein thermodilution technique. Additionally, the study will validate this invasive method with contrast-enhanced ultrasound of the kidneys to provide a comprehensive understanding of renal physiology during treatment.
Who should consider this trial
Good fit: Ideal candidates are ICU patients aged 18 and older with stage 2 or 3 AKI and preserved urine production.
Not a fit: Patients requiring emergency dialysis or those with allergies to contrast media will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved dialysis protocols that enhance kidney function and patient outcomes in ICU settings.
How similar studies have performed: While there is conflicting data on dialysis timing, this specific investigation into renal physiology during CRRT at varying blood pressures is novel and has not been extensively studied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: AKI, according to KDIGO, stage 2 or 3 but with preserved urine production. Treated in the ICU at Sahlgrenska University Hospital Written, signed informed consent Male and female subjects ≥18 years Exclusion Criteria: Emergency need for dialysis Allergy to contrast media (used for CEUS)
Where this trial is running
Gothenburg
- Sahlgrenska University Hospital — Gothenburg, Sweden (Recruiting)
Study contacts
- Principal investigator: Kristina Svennerholm, MD PhD
- Study coordinator: Kristina Svennerholm, MD PhD
- Email: kristina.svennerholm@vgregion.se
- Phone: +46313429336
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.