Investigating Inflammation in Arrhythmogenic Right Ventricular Cardiomyopathy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the role of local inflammation in patients diagnosed with arrhythmogenic right ventricular cardiomyopathy (ARVC). It will assess the presence of inflammatory components in the heart using advanced cardiac electrophysiologic techniques and immunological assessments on both venous blood and intracardiac material. The research seeks to document the feasibility of detecting these inflammatory markers, which may contribute to the understanding of ARVC pathophysiology and potential new therapeutic targets. By mapping the right ventricle and analyzing local cardiomyocytes, the study hopes to uncover insights into the disease's progression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* For cases:

  * Arrhythmogenic right ventricular dysplasia diagnosed (according to 2010 Task Force Criteria)
  * Admitted for right ventricle electrophysiologic mapping
* For controls \* Admitted for ablation procedures (accessory pathway, atrial flutter) on otherwise healthy hearts.

Exclusion Criteria:

* Diagnostic of systemic chronic inflammatory disease
* Presence of possible or proven cardiac involvement of an inflammatory disease, an acute or chronic infectious disease.
* Taking immunosuppressant or immunomodulating medications

Where it's running

• Toulouse University Hospital Center
  Toulouse, France Recruiting

Study contacts

• Principal investigator: Philippe MAURY, MD — University Hospital, Toulouse
• Study coordinator: Philippe MAURY, MD
• Email: maury.p@chu-toulouse.fr
• Phone: 5 61 32 34 70

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• Blocking a hormone system to treat heart issues in ARVD patients

  This study is testing if the medication spironolactone can help people with Arrhythmogenic Right Ventricular Dysplasia (ARVD) by slowing down heart problems and reducing irregular heartbeats.

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• Registry and biobank for arrhythmogenic ventricular cardiomyopathy

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.