Investigating how mitochondrial factors affect blood pressure differences between races
The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function
NA · Auburn University · NCT04334135
This study is testing whether a mitochondrial antioxidant called MitoQ can help lower blood pressure and improve blood vessel function in black and white adults with high blood pressure to better understand racial differences in hypertension.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 19 Years to 75 Years |
| Sex | All |
| Sponsor | Auburn University (other) |
| Locations | 1 site (Auburn, Alabama) |
| Trial ID | NCT04334135 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the role of mitochondrial-derived reactive oxygen species in influencing blood vessel function and blood pressure regulation, particularly focusing on racial disparities between black and white individuals. It seeks to understand why black adults experience higher rates of hypertension and cardiovascular disease despite advancements in treatment options. The study will involve administering MitoQ, a mitochondrial antioxidant, to assess its effects on blood pressure and vascular function in participants with elevated blood pressure. By identifying the underlying mechanisms of these disparities, the research hopes to contribute to more effective preventive strategies.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 19-75 with blood pressure no higher than 150/90 mmHg and a BMI below 35.
Not a fit: Patients with a history of cardiovascular disease, diabetes, or renal disease, as well as those with high blood pressure or obesity, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment of hypertension in black individuals, potentially reducing cardiovascular disease risk.
How similar studies have performed: While there have been studies on mitochondrial antioxidants improving vascular function, this specific investigation into racial disparities is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Are between the ages of 19-75. * Have blood pressure no higher than 150/90 mmHg. * Have a BMI below 35 Kg/m2 (otherwise healthy) * Free from metabolic disease (diabetes or renal disease), pulmonary disorders (e.g., COPD \& cystic fibrosis), and cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular). * Do not have any precluding medical issues that prevent participants from exercising (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis) or giving blood (e.g., blood thinners). * Are not currently smoking, using smokeless tobacco, nor smoked within the past 12 months. Exclusion Criteria: * Known allergy to MitoQ * High blood pressure - greater the 150/90 mmHg * Low blood pressure - less than 90/50 mmHg * History of cardiovascular disease * History of cancer * History of diabetes * History of kidney disease * Obesity (BMI \> 30 kg/m2) * Smoking or tobacco use * Current pregnancy * Nursing mothers * Communication barriers
Where this trial is running
Auburn, Alabama
- Kinesiology Building — Auburn, Alabama, United States (RECRUITING)
Study contacts
- Study coordinator: Austin T Robinson, PhD
- Email: atr0026@auburn.edu
- Phone: 334 844 1619
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Racial Disparities, Blood Pressure, Cardiovascular Risk Factor, Renal Function, blood pressure, hypertension, cardiovascular health, renal function