Investigating how bariatric surgery affects the absorption of valsartan
Bariatric Surgery and Pharmacokinetics of Valsartan: BAR-MEDS Valsartan
This study is testing how bariatric surgery affects how well the heart medication valsartan is absorbed in patients getting gastric bypass or sleeve gastrectomy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 12 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Norwegian University of Science and Technology Academic / other |
| Locations | 1 site (Trondheim) |
| Trial ID | NCT03535376 on ClinicalTrials.gov |
What this trial studies
This observational study examines the pharmacokinetics of valsartan in patients preparing for gastric bypass or sleeve gastrectomy. It aims to understand how changes in gastric pH, gastric emptying time, and gastrointestinal transit time due to bariatric surgery may influence the biological availability of this medication. By analyzing these effects, the study seeks to provide insights into optimal medication management for patients undergoing these surgical procedures.
Who should consider this trial
Good fit: Ideal candidates are Norwegian citizens preparing for gastric bypass or sleeve gastrectomy in Central Norway.
Not a fit: Patients who have previously undergone resections in the gastrointestinal tract may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved medication dosing and effectiveness for patients who have undergone bariatric surgery.
How similar studies have performed: While there is limited research specifically on valsartan, similar studies have shown that bariatric surgery can significantly alter pharmacokinetics of various medications.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway * Being a Norwegian citizen Exclusion Criteria: * Having previously undergone resections in the GI-tract
Where this trial is running
Trondheim
- St. Olavs University Hospital — Trondheim, Norway (Recruiting)
Study contacts
- Principal investigator: Magnus Strømmen, MSc — St. Olavs Hospital
- Study coordinator: Magnus Strømmen, MSc
- Email: magnus.strommen@stolav.no
- Phone: 0047 72829970
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.