Investigating hormone differences in cardiac surgery patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study examines the differences in plasma hormone concentrations of the renin-angiotensin-aldosterone system (RAAS) between patients undergoing on-pump versus off-pump cardiac surgery. It aims to understand how cardiopulmonary bypass may influence the incidence of vasoplegia or vasoplegic shock, a serious complication during cardiac procedures. By analyzing hormone levels, the study seeks to clarify the role of pulmonary circulation in regulating vascular tension and blood pressure during surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. adult patients undergoing on- or off-pump coronary artery bypass graft surgery
2. written informed consent

Exclusion Criteria:

1. emergency surgery in the context of acute coronary syndrome
2. ACE-inhibitor or Angiotensin 1 (AT1)-receptor-blocker intake that was not paused on the day of surgery
3. Chronic kidney disease with estimated glomerular filtration rate (eGFR)\<30ml/min/1.73m²
4. Severe structural lung disease (asbestosis, silicosis, severe sarcoidosis, tuberculosis, severe emphysema, chronic obstructive pulmonary disease (COPD) Gold 3-4, lung fibrosis)
5. Chronic pulmonary hypertension
6. Pregnancy or breastfeeding
7. Persons with any kind of dependency on the investigator or employed by the institution responsible or investigator
8. Persons held in an institution by legal or official order

Where it's running

• Deutsches Herzzentrum der Charité
  Berlin, Germany Recruiting
• University Hospital Münster; Department of Anesthesiology, Intensive Care Medicine and Pain Medicine
  Münster, Germany Recruiting

Study contacts

• Study coordinator: Alexander Zarbock, MD
• Email: aki@anit.uni-muenster.de
• Phone: +492518347255

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.