Investigating dendritic cells in skin graft-versus-host disease
Analysis of Dendritic Cells in Patients With Acute or Chronic Skin Graft Versus Host Disease
This study looks at how certain immune cells called dendritic cells affect skin graft-versus-host disease in patients to help find better ways to manage the condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Washington University School of Medicine Academic / other |
| Locations | 1 site (Saint Louis, Missouri) |
| Trial ID | NCT02611180 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on understanding the role of dendritic cells (DCs) in patients with acute or chronic skin graft-versus-host disease (GVHD). It involves collecting skin punch biopsies and peripheral blood samples to analyze different subsets of DCs and their potential impact on immune responses. The study aims to identify how these immune cells contribute to the development and progression of skin GVHD, which could lead to better management strategies for affected patients.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older with a current or suspected diagnosis of acute or chronic skin graft-versus-host disease.
Not a fit: Patients with known infections such as Hepatitis B or C, HTLV, or HIV, as well as pregnant females, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of skin GVHD and lead to improved treatment options for patients suffering from this condition.
How similar studies have performed: While the specific role of dendritic cells in skin GVHD is not extensively studied, similar approaches in understanding immune responses have shown promise in other conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * At least 18 years of age at enrollment * Willing and able to sign the informed consent * Current diagnosis/suspected diagnosis of acute skin GVHD OR Current diagnosis/suspected diagnosis of chronic skin GVHD Exclusion Criteria: * Known infection with Hepatitis B or C, HTLV, or HIV * Pregnant females
Where this trial is running
Saint Louis, Missouri
- Washington University School of Medicine — Saint Louis, Missouri, United States (Recruiting)
Study contacts
- Principal investigator: Eynav Klechevsky, Ph.D. — Washington University School of Medicine
- Study coordinator: Eynav Klechevsky, Ph.D.
- Email: eklechevsky@wustl.edu
- Phone: 314-286-0897
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.