Investigating colchicine for heart failure with preserved ejection fraction

The COLchicine HEART Failure PRESERVED Trial (COLHEART-PRESERVED)

This study is testing whether a low dose of colchicine can improve heart function and quality of life for people with heart failure and preserved ejection fraction.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 152 (estimated)
• Ages: 40 Years and up
• Sex: All
• Sponsor: Herlev and Gentofte Hospital (Academic / other)
• Locations: 1 site (Hellerup)
• Trial ID: NCT06081049 on ClinicalTrials.gov

What this trial studies

This study aims to evaluate the effects of colchicine on health status, quality of life, and cardiac function in patients with heart failure with preserved ejection fraction (HFpEF). It is a randomized, double-blind, placebo-controlled trial involving approximately 152 patients aged 40 and older who exhibit symptoms of HFpEF. Participants will receive either low-dose colchicine or a placebo for six months, with assessments including the Kansas City Cardiomyopathy Questionnaire and echocardiography at baseline and after treatment. Additional evaluations will include blood pressure, ECG, and other cardiovascular measures.

Who should consider this trial

Good fit: Ideal candidates are adults aged 40 and above with diagnosed heart failure with preserved ejection fraction and specific cardiac abnormalities.

Not a fit: Patients with heart failure not meeting the inclusion criteria or those with a body mass index over 40 kg/m2 may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve the management and quality of life for patients suffering from heart failure with preserved ejection fraction.

How similar studies have performed: Other studies have explored colchicine's effects on cardiovascular conditions, but this specific application in HFpEF is novel.

Eligibility criteria

Inclusion Criteria:

* LVEF ≥ 45% judged by echocardiography during the screening epoch or within 6 months prior to screening visit
* Symptom(s) of heart failure for at least 30 days prior to screening visit and current symptoms of heart failure (NYHA functional class II-IV) at screening visit
* Objective evidence of cardiac structural and/or functional abnormalities consistent with the presence of LV diastolic dysfunction/raised LV filling pressures (left atrial enlargement and/or left ventricular hypertrophy) judged by echocardiography at screening epoch or within 12 months prior to screening visit
* Raised pro-BNP ≥ 125 pg/ml (sinus rhythm) or ≥ 300 pg/ml (atrial fibrillation (AF)).
* Body Mass Index (BMI) \< 40 kg/m2 at screening visit
* Female patients should either not be of childbearing potential, defined as postmenopausal for at least 1 year or surgically sterile, or of childbearing potential and practicing one of the following methods of contraception throughout the study and for 30 days after study completion: Hormonal contraception (oral contraceptives, contraceptive implant, injectable birth control, contraceptive patch, or vaginal ring) or intrauterine device
* Patients will have given written, informed consent and are able and willing to comply with the requirements of the study protocol

Exclusion Criteria:

* Colchicine treatment for another cause, e.g., gout
* Allergy/hypersensitivity to colchicine
* Uncontrolled hypertension (systolic BP \>180 mmHg or diastolic BP \>110 mmHg)
* History of malignancy of any organ system excluding a successfully treated non-metastatic cutaneous squamous cell or basal cell carcinoma, localized prostate cancer and/or localized carcinoma in situ of the cervix
* Cirrhosis, chronic active hepatitis, or other severe hepatic disease
* Hemodialysis
* Estimated glomerular filtration rate (eGFR) \< 35 mL/min/1.73 m2
* Systemic treatment with moderate or strong cytochrome P450 3A4 (CYP3A4) inhibitors or P-glycoprotein inhibitors
* Anemia, thrombocytopenia, or leucopenia defined as any of the following measurements within the last 3 months:

  * Hemoglobin \< 7 mmol/L
  * Platelet count \< 110 x 109/L
  * White blood cell count \< 3.0 x 109/L
* Acute decompensated heart failure (hospitalization for heart failure within 7 days prior to screening visit)
* Acute coronary syndrome (including MI), cardiac surgery, other major cardiovascular surgery, ablation of atrial flutter/fibrillation, valve repair/replacement, implanted cardioverter defibrillator or urgent PCI within 3 months prior to screening visit or an elective PCI within 30 days prior to screening visit
* Planned coronary revascularization (percutaneous intervention or surgical), major cardiac surgery (coronary artery bypass grafting, valve repair/replacement, ventricular assist device, cardiac transplantation, or any other surgery requiring thoracotomy), CRT or ablation of atrial flutter/fibrillation during the trial
* Any clinical event within 6 months prior to screening visit that could have reduced LVEF (e.g., MI, CABG), unless echocardiographic measurement was performed after the event confirming LVEF ≥ 45%
* Stroke, transient ischemic attack, carotid surgery, or carotid angioplasty within 3 months prior to screening visit
* Previous cardiac transplantation, complex congenital heart disease or cardiac resynchronization therapy
* Heart failure due to any of the following: known infiltrative cardiomyopathy, active myocarditis, constrictive pericarditis, cardiac tamponade, known genetic hypertrophic cardiomyopathy, obstructive cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy or uncorrected severe/hemodynamically significant valvular heart disease
* Life threatening or uncontrolled dysrhythmia, including symptomatic or sustained ventricular tachycardia and AF or atrial flutter with a resting ventricular rate \> 110 beats per minute
* Evidence of right-sided HF in the absence of left sided structural heart disease
* Probable alternative diagnosis that in the opinion of the investigator could account for the patient's HF symptoms (i.e., anemia, hypothyroidism, severe obesity)
* World Health Organization Group 1 pulmonary hypertension, chronic pulmonary embolism, severe pulmonary disease, including COPD (i.e., requiring home oxygen, chronic nebulizer therapy or chronic oral steroid therapy, or hospitalization for exacerbation of COPD requiring ventilatory assist within 12 months prior to enrollment)
* Female patients who are pregnant, lactating, or considering becoming pregnant during the study or for 6 months after study completion
* Significant drug or alcohol abuse during the last year
* Current use of or plans to initiate chronic systemic steroid therapy during the study (topical or inhaled steroids are allowed)
* Chronic inflammatory bowel disease (Crohn's disease or ulcerative colitis) or chronic diarrhea
* Use of other investigational drugs within 30 days of the time of enrollment
* Any surgical or medical condition, which in the opinion of the investigator, may place the patient at higher risk from his/her participation in the study, or is likely to prevent the patient from complying with the requirements of the study or completing the study
* Life expectancy \< 2 years at the screening visit

Where this trial is running

Hellerup

• Center for Translational Cardiology and Pragmatic Randomized Trials, Herlev and Gentofte Hospital — Hellerup, Denmark (Recruiting)

Study contacts

• Principal investigator: Camilla Ikast Ottosen, MD — Herlev and Gentofte Hospital
• Study coordinator: Camilla Ikast Ottosen, MD

Conditions Heart Failure With Preserved Ejection Fraction; Randomized Controlled Trial; Cardiovascular Diseases; Heart Diseases; Colchicine; Inflammation; Echocardiography; Hypertrophy, Left Ventricular