Investigating causes and early detection of infections after major abdominal surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the mechanisms behind postoperative infections following major abdominal surgeries, particularly in cancer patients. It will analyze the preoperative microbiome from patients' gut and oral cavities to determine if pathogens from these areas contribute to surgical site infections. Additionally, the study will collect biological samples to identify biomarkers that may predict the likelihood of developing infections post-surgery. By challenging the traditional understanding of infection sources, this research seeks to provide new insights into infection prevention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. The patient is scheduled to undergo a major resection-type abdominal surgery due to cancer of the esophagus, stomach, pancreas, liver, bile ducts, colon or rectum.
2. Patient is willing to participate.
3. Age ≥ 18 years.

Exclusion Criteria:

1. Pregnancy.
2. Previous surgical resection of the digestive tract, excluding appendectomy and/or cholecystectomy.
3. Anticipated operation with preventive ileostomy.
4. The operation is planned to be performed as a matter of urgency.
5. Antibiotic therapy ≤1 month. before surgery.
6. Chronic inflammatory bowel disease (non-specific ulcerative colitis, Crohn's disease) or radiation or other colitis of origin.
7. During the last year, the patient suffered from Cl. difficile colitis or was Cl. difficile carrier, had salmonellosis or others intestinal infections.
8. During the last year, the patient used (\> 3 months) pre-/pro-/(syn)biotics.
9. During the last year, the patient has been taking proton pump inhibitors continuously (\> 6 months).

Where it's running

• National Cancer Institute
  Vilnius, Lithuania Recruiting
• Vilnius University hospital Santaros Klinikos
  Vilnius, Lithuania Recruiting

Study contacts

• Study coordinator: Augustinas Bausys
• Email: augustinas.bausys@nvi.lt
• Phone: 37062214027

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.