Investigating cancer incidence in Parkinson's patients with a specific gene mutation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter retrospective observational study examines the incidence of malignant neoplasms in patients with Parkinson's disease (PD) who carry heterozygous mutations in the GBA1 gene. It compares these patients to those with idiopathic PD and the general population using data from local cancer registries. The study aims to determine if there is a higher incidence of cancer among GBA1 mutation carriers and to characterize the types of cancers present. Approximately 3000 PD patients will be included, with a focus on understanding the relationship between genetic factors and cancer risk.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* \>18 years
* Diagnosis of Parkinson's Disease through the United Kingdom Parkinson's Disease Society Brain Bank Diagnostic Criteria for Parkinson's Disease.

Exclusion Criteria:

* Uncertain diagnosis

Where it's running

• Ospedale A. Perrino
  Brindisi, Italy Recruiting
• IRCCS Istituto Neurologico Carlo Besta
  Milan, Italy Recruiting
• Azienda USL IRCCS di Reggio Emilia
  Reggio Emilia, Italy Recruiting
• Ospedale Santa Chiara di Trento
  Trento, Italy Recruiting

Study contacts

• Study coordinator: Giulia Di Rauso, MD
• Email: giulia.dirauso@ausl.re.it
• Phone: +39 0522 296494

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.