Investigating brain sugar levels in patients with severe brain injury
Microdialysis and Jugular Bulb Glucose Profiles During Hyperglycaemic Clamping in Patients with Severe Acute Brain Injury
This study is testing how blood sugar levels affect brain sugar levels in patients with severe brain injuries to better understand their metabolism and treatment needs.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 14 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Rigshospitalet, Denmark Academic / other |
| Locations | 2 sites (Copenhagen and 1 other locations) |
| Trial ID | NCT06393049 on ClinicalTrials.gov |
What this trial studies
This study examines the relationship between blood sugar levels and brain sugar levels in patients suffering from severe acute brain injury. Using multimodal neuromonitoring, researchers will measure glucose levels in both arterial and venous blood, as well as in brain tissue through microdialysis. The goal is to develop a mathematical model that describes how the brain absorbs sugar, which could enhance understanding of metabolic processes in critically ill patients. This research aims to clarify the interaction between systemic and cerebral glucose levels during hyperglycaemic clamping.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are admitted to the neuro-ICU with multimodal neuromonitoring.
Not a fit: Patients with known diabetes mellitus upon admission may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the management of glucose levels in patients with acute brain injuries, potentially leading to better outcomes.
How similar studies have performed: While the approach of using multimodal neuromonitoring is common, the specific investigation of glucose dynamics in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years. * Admission to the neuro-ICU at Rigshospitalet. * Multimodal neuromonitoring Exclusion Criteria: * Closest relative does not understand written and spoken Danish or English. * Patients with known diabetes mellitus upon admission.
Where this trial is running
Copenhagen and 1 other locations
- Department of Neuroanaesthesiology, Rigshospitalet — Copenhagen, Denmark (Recruiting)
- Rigshospitalet — Copenhagen, Denmark (Recruiting)
Study contacts
- Study coordinator: Anne-Sophie Worm Fenger, MD
- Email: anne-sophie.fenger.03@regionh.dk
- Phone: +4524624359
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.