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Clinical trial No longer in our active list Interventional Ages 10 to 50

Investigating brain and eye movement responses to emotional facial expressions in autism and psychotic disorders

Official title: Brain and Oculometric Markers of Emotional Facial Expression Recognition Deficits Associated With Autistic and Psychotic Symptoms

Run by Hôpital le Vinatier · NCT05501405 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is trying to see how people with autism and psychotic disorders recognize emotions on faces by looking at their brain activity and eye movements.

More Autism trials

Quick facts

Study typeInterventional
Ages10 Years to 50 Years
SexAll
Enrollment210 (estimated)
SponsorHôpital le Vinatier
Academic / other
Locations1 site (Lyon, Rhône)
Trial IDNCT05501405 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include individuals aged 10 to 50 with autism spectrum disorder, schizophrenia, or specific genetic conditions affecting emotional recognition.

Probably not a fit

Patients with recent addictions, significant neurological disorders, or uncorrected visual acuity issues may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore how individuals with autism and psychotic disorders recognize emotional facial expressions using a novel approach called Fast Periodic Visual Stimulation (FPVS) combined with electroencephalography (EEG). By analyzing brain activity and eye-tracking data, the researchers will assess the neural and visual exploration patterns associated with facial emotion recognition deficits. The study focuses on individuals with specific genetic conditions, schizophrenia, or autism, aged 10 to 50, who are French speakers and have stable symptoms. The goal is to better understand the cognitive mechanisms underlying these recognition difficulties.

Why it matters

Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for individuals with autism and psychotic disorders.

How similar studies have gone: Previous studies using similar FPVS-EEG approaches have shown success in understanding emotional recognition in atypical populations, indicating potential for this study's methodology.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Individuals with a genetic condition with psychiatric expression (22q11.2 microdeletion syndrome, Williams syndrome, Präder-Willi syndrome)
* Individuals with schizophrenia according to DSM-5 criteria
* Individuals with Autism Spectrum Disorder (ASD) according to DSM-5 criteria
* Individuals between the ages of 10 and 50
* French native language
* Psychotropic treatment unchanged during the month preceding inclusion
* Stable symptomatology
* Individuals having given their informed consent to participate in the study (consent of legal tutors for minors or under tutorship

Exclusion Criteria:

* Recent addiction, excluding tobacco addiction (according to DSM-5 criteria)
* Neurological disorders of vascular, infectious or neurodegenerative origin for patients with schizophrenia or ASD
* Uncorrected visual acuity disorder
* Use of somatic medications that have a cerebral or psychological impact (e.g. corticosteroids)
* Pregnant women

Where it's running

  • centre de réhabilitation - Hôpital le Vinatier
    Lyon, Rhône, France     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Autism 558Psychotic Disorders 46Hôpital le Vinatier 30
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.