Investigating brain activity patterns in Parkinson's disease during movement
Official title: Parkinsonism-Related Oscillations in the Cortico-Basal Ganglia-Thalamic Network During Movement: Beyond the Frequency Range
Run by University Hospital, Bordeaux · NCT06438419 · Data updated 2026-11-12
This study is testing how brain activity during movement relates to symptoms in people with Parkinson's disease who have had deep brain stimulation to see if it can help improve their treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | University Hospital, Bordeaux Academic / other |
| Locations | 1 site (Bordeaux) |
| Status | Recruiting |
| Started | April 16, 2025 |
| Main results expected | April 2027 |
| Study ends | April 2027 |
| Registry record updated | May 2, 2025 |
| Trial ID | NCT06438419 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 to 75 with idiopathic Parkinson's disease who have undergone STN-DBS or are candidates for the procedure.
✕Probably not a fit
Patients who are unable to provide informed consent or have serious psychiatric or somatic illnesses may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to explore the relationship between neuronal oscillations in the cortico-subcortical network and motor performance in patients with Parkinson's disease who have undergone subthalamic deep brain stimulation (STN-DBS). Using high-resolution EEG, the research will collect local field potentials during a simple motor task under various pharmacological and stimulation conditions. The goal is to understand how these oscillations correlate with hypokinetic and hyperkinetic symptoms, potentially leading to improved treatment strategies for Parkinson's disease.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of Parkinson's disease and lead to better-targeted therapies for managing motor symptoms.
How similar studies have gone: While there have been studies on neuronal oscillations in Parkinson's disease, this specific approach using high-resolution EEG and the PERCEPT™ system is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or Female * 18 to 75 years-old * With idiopathic Parkinson's disease * Having a STN-DBS with a PERCEPT™ for less than a year or being candidate for STN-DBS with the PERCEPT™ device (first-implantation) * Able to perform the simple motor task * Patients covered by a health insurance scheme * Giving free, informed, written consent signed by the participant and the investigator. Exclusion Criteria: * Be incapable of giving consent personally. * Be subject to a legal protection measure (curatorship, guardianship) or be placed under judicial protection. * Being pregnant or breastfeeding * Present a serious and/or decompensated somatic or psychiatric illness.
Where it's running
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Bordeaux University Hospital
Bordeaux, France Recruiting
Study contacts
- Study coordinator: GUEHL Dominique, Pr
- Email: dominique.guehl@chu-bordeaux.fr
- Phone: 5 57 82 12 42
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.