Investigating brain activity patterns in Parkinson's disease during movement
Parkinsonism-Related Oscillations in the Cortico-Basal Ganglia-Thalamic Network During Movement: Beyond the Frequency Range
This study is testing how brain activity during movement relates to symptoms in people with Parkinson's disease who have had deep brain stimulation to see if it can help improve their treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | University Hospital, Bordeaux Academic / other |
| Locations | 1 site (Bordeaux) |
| Trial ID | NCT06438419 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the relationship between neuronal oscillations in the cortico-subcortical network and motor performance in patients with Parkinson's disease who have undergone subthalamic deep brain stimulation (STN-DBS). Using high-resolution EEG, the research will collect local field potentials during a simple motor task under various pharmacological and stimulation conditions. The goal is to understand how these oscillations correlate with hypokinetic and hyperkinetic symptoms, potentially leading to improved treatment strategies for Parkinson's disease.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 to 75 with idiopathic Parkinson's disease who have undergone STN-DBS or are candidates for the procedure.
Not a fit: Patients who are unable to provide informed consent or have serious psychiatric or somatic illnesses may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of Parkinson's disease and lead to better-targeted therapies for managing motor symptoms.
How similar studies have performed: While there have been studies on neuronal oscillations in Parkinson's disease, this specific approach using high-resolution EEG and the PERCEPT™ system is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or Female * 18 to 75 years-old * With idiopathic Parkinson's disease * Having a STN-DBS with a PERCEPT™ for less than a year or being candidate for STN-DBS with the PERCEPT™ device (first-implantation) * Able to perform the simple motor task * Patients covered by a health insurance scheme * Giving free, informed, written consent signed by the participant and the investigator. Exclusion Criteria: * Be incapable of giving consent personally. * Be subject to a legal protection measure (curatorship, guardianship) or be placed under judicial protection. * Being pregnant or breastfeeding * Present a serious and/or decompensated somatic or psychiatric illness.
Where this trial is running
Bordeaux
- Bordeaux University Hospital — Bordeaux, France (Recruiting)
Study contacts
- Study coordinator: GUEHL Dominique, Pr
- Email: dominique.guehl@chu-bordeaux.fr
- Phone: 5 57 82 12 42
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.