Invasive Genetic Testing in fetuses with isolated IUGR diagnosed after 28 weeks
Official title: Assessment of Invasive Genetic Testing Procedures in Fetuses With Isolated Intrauterine Growth Restriction (IUGR) Diagnosed After 28 Weeks of Gestation at Strasbourg University Hospitals Between 2016 and 2023
Run by University Hospital, Strasbourg, France · NCT07864272 · Data updated 2026-11-12
This study looks at how often invasive genetic tests are done in late-pregnancy fetuses with isolated IUGR and what kinds of results they yield.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 200 (estimated) |
| Sponsor | University Hospital, Strasbourg, France Academic / other |
| Locations | 1 site (Strasbourg) |
| Status | Recruiting |
| Started | January 12, 2026 |
| Main results expected | December 12, 2026 |
| Study ends | January 12, 2027 |
| Registry record updated | October 7, 2026 |
| Trial ID | NCT07864272 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Pregnancies with isolated IUGR diagnosed after 28 weeks, managed at Strasbourg University Hospitals between 2016 and 2023, where there was no documented opposition to reuse of medical data for research.
✕Probably not a fit
Pregnancies with concurrent fetal anomalies, multiple pregnancies, or incomplete genetic workups are less likely to benefit from invasive testing or may yield limited information.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a retrospective, single-center analysis conducted at Strasbourg University Hospitals from 2016 to 2023. It examines the use and diagnostic yield of invasive prenatal genetic testing (such as amniocentesis) in pregnancies with isolated intrauterine growth restriction diagnosed after 28 weeks. The study uses data from the DIAMM database and supplements it with DEFGEN postnatal results to understand indications, procedures performed, and factors influencing decision-making. Exclusion criteria include suspected fetal anomalies, multiple pregnancies, and incomplete genetic workups. Findings aim to clarify when invasive testing provides useful information and to inform clinical counseling.
Why it matters
Potential benefit: Results could help clinicians better counsel expectant parents on whether invasive genetic testing is likely to provide actionable information in late-gestation IUGR with no other anomalies.
How similar studies have gone: Previous studies have shown mixed yields for invasive fetal testing in isolated IUGR, making this largely observational and context-specific.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Maternal age ≥ 18 years * Referral after 28 weeks of gestation for estimated fetal weight \< 3rd percentile, isolated condition * Management at Strasbourg University Hospitals between 01/01/2016 and 01/01/2023 * No documented opposition to reuse of medical data for research Exclusion Criteria: * Suspected fetal structural anomaly or infectious cause * Multiple pregnancy * Incomplete genetic workup
Where it's running
-
Service de Gynécologie et Obstétrique - CHU de Strasbourg - France
Strasbourg, France Recruiting
Study contacts
- Study coordinator: Marie-Laure LEGRIS, MD
- Email: marie-laure.legris@chru-strasbourg.fr
- Phone: 33 3 88 12 73 02
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.