Intrauterine Adhesion Prevention With a Uterine Stent After Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter randomized trial compares a uterine stent to a standard regimen of intrauterine rings, balloons, and sodium hyaluronate gel after hysteroscopic adhesion separation. It aims to determine safety and effectiveness for preventing intrauterine adhesions, using a non-inferiority design with 200 participants. Participants undergo a 3-cycle artificial hormonal regimen followed by hysteroscopy review to assess outcomes. Eligible women have fertility or drainage concerns and meet specified health criteria, while certain uterine conditions and medical histories exclude enrollment. The study is led by The Third Xiangya Hospital with several collaborating centers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients clinically diagnosed with intrauterine adhesions and with surgical indications (referring to those with fertility requirements or obstructed menstrual blood drainage) ② Women aged 20-40 years old; ③ Subjects voluntarily participated in the trial and signed informed consent.

Exclusion Criteria:

* ① Patients with obviously abnormal uterine cavity shape after surgery; those who could not clearly separate the normal uterine cavity anatomical morphology (i.e. bilateral or unilateral fallopian tube openings were not visible); those with reproductive organ malformations and uterine cavities that were too large or too small; those with recent uterine perforation; those with cervical insufficiency.

  * Those with a history of intrauterine adhesions and treatment;

    * Those with endometrial tuberculosis or suspected endometrial tuberculosis;

      * Those with adenomyosis or uterine fibroids\>4cm;

        * Those with a history of malignant tumors or suspected malignant tumors;

          * Those with acute and chronic intrauterine infection and genital infection;

            * Those with unexplained vaginal bleeding or suspected uterine malignant lesions;

              * Those with severe anemia and abnormal coagulation function; those with a history of thrombosis; ⑨ Those in the acute stage of various diseases or severe systemic diseases;

                * Those with severe mental illness and physical weakness who cannot tolerate this operation;

                  ⑪ Those with severe heart, liver, and kidney function diseases;

                  ⑫ Those with contraindications to anesthesia or surgery;

                  ⑬ Those who have participated in clinical trials in the past three months.
                  * Those who are considered unsuitable for inclusion by the researchers.

Where it's running

• The Third Xiangya Hospital of Central South University
  Changsha, Hunan, China Recruiting

Study contacts

• Study coordinator: Dabao MD
• Email: forxudabao@126.com
• Phone: 13017386201

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• A combined 4D ultrasound, hysteroscopic cold-knife plowing, uterine stent, and traditional Chinese medicine approach for intrauterine adhesions

  This project will try a combined care pathway—preoperative 4D ultrasound, hysteroscopic cold-knife adhesion separation, a postoperative uterine stent, and traditional Chinese medicine—to see if it improves outcomes for women aged 18–45 with intrauterine adhesions.

  Recruiting The Third Xiangya Hospital of Central South University · Changsha, Hunan · NCT07421908

• Intrauterine Stent Placement After Septum Resection

  This trial tests whether placing a small intrauterine balloon stent for 7-10 days after hysteroscopic septum removal helps prevent scar tissue formation in people with a uterine septum.

  Recruiting Weill Medical College of Cornell University · Little Rock, Arkansas and 2 other locations · NCT07032506

• Using engineered stem cell exosomes to treat thin endometrial lining in women

  This study tests if a new treatment using special stem cell particles can help women with a thin uterine lining get thicker linings compared to standard treatments.

  Recruiting at 2 sites Phase 1/2 Tang-Du Hospital · Xi'an, Shaanxi and 1 other locations · NCT06896747

• Using Platelet-rich Plasma to Improve Female Fertility

  This study is testing whether injections of platelet-rich plasma can help improve fertility in women dealing with issues like poor ovarian response and repeated implantation failure.

  Recruiting The Fourth Affiliated Hospital of Zhejiang University School of Medicine · Yiwu, Zhejiang · NCT06645379

• Comparing heparin solution and barrier gel for preventing intrauterine adhesions after surgery

  This study is testing whether a heparin solution or a barrier gel is better at preventing scar tissue in the uterus after surgery for women who have had operative hysteroscopy.

  Recruiting at 2 sites Nadezhda Women's Health Hospital · Sofia, Sofia and 1 other locations · NCT05257213

• Comparison of operative hysteroscopy vs vacuum aspiration for first-trimester termination with intrauterine adhesions

  In people with early pregnancy and intrauterine adhesions, this study tests whether hysteroscopy with adhesiolysis plus vacuum aspiration is safer or more effective than vacuum aspiration alone for terminating the pregnancy.

  Recruiting Women's Hospital School Of Medicine Zhejiang University · Hangzhou · NCT07883057

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.