Comparison of operative hysteroscopy vs vacuum aspiration for first-trimester termination with intrauterine adhesions
Official title: Comparison of Operative Hysteroscopy and Vacuum Aspiration for Terminating First-trimester Pregnancy With Intrauterine Adhesions: A Prospective Observational Study
Run by Women's Hospital School Of Medicine Zhejiang University · NCT07883057 · Data updated 2026-11-12
In people with early pregnancy and intrauterine adhesions, this study tests whether hysteroscopy with adhesiolysis plus vacuum aspiration is safer or more effective than vacuum aspiration alone for terminating the pregnancy.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 40 Years |
| Sex | Women only |
| Enrollment | 360 (estimated) |
| Sponsor | Women's Hospital School Of Medicine Zhejiang University Academic / other |
| Locations | 1 site (Hangzhou) |
| Status | Recruiting |
| Started | December 2026 |
| Main results expected | August 2030 |
| Study ends | August 2030 |
| Registry record updated | October 20, 2026 |
| Trial ID | NCT07883057 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people with ultrasound-confirmed intrauterine adhesions who desire future fertility and have no significant organic diseases.
✕Probably not a fit
Patients without intrauterine adhesions or with conditions contraindicating hysteroscopy may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study compares two approaches for terminating a first-trimester pregnancy in people with intrauterine adhesions. It examines whether performing hysteroscopy to visualize and treat adhesions during the procedure reduces incomplete abortion, retained tissue, or need for reoperation compared with standard vacuum aspiration. The investigation also considers how concurrent adhesiolysis may affect future uterine health and fertility by improving uterine cavity structure. Follow-up includes ultrasound assessments over at least three months to monitor outcomes. The study is conducted at a single center with the lead sponsor coordinating the observational analysis.
Why it matters
Potential benefit: If successful, hysteroscopy with adhesiolysis plus vacuum aspiration could lower complication rates and preserve fertility for people with IUAs facing early pregnancy termination.
How similar studies have gone: Previous experiences with hysteroscopy for IUA management suggest potential benefits, but data in this specific terminologic combination for first-trimester termination are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. patients with transvaginal ultrasound findings suggestive of IUA; 2. patients who underwent follow-up postoperative ultrasound examinations for 3 or more months at the study hospital; 3. patients with a desire to bear children; 4. patients with no significant organic diseases. Exclusion Criteria: 1. patients with ectopic pregnancies, e.g., a cesarean scar pregnancy, angular pregnancies, or a cervical pregnancy; 2. patients who underwent other intrauterine surgical procedures, such as endometrial polypectomy, submucosal myomectomy, or uterine septum resection, during hysteroscopy; 3. patients who underwent medical termination of pregnancy with oral mifepristone plus misoprostol without surgery; 4. patients with abnormal postoperative pathological results, e.g., molar pregnancy; 5. patients without follow-up data or ultrasound results or with incomplete data for 3 months after surgery; 6. patients whose initial surgery was not performed at the study hospital.
Where it's running
-
Women's Hospital, Zhejiang University School of Medicine
Hangzhou, China Recruiting
Study contacts
- Study coordinator: Jiang Xiuxiu
- Email: 5515036@zju.edu.cn
- Phone: +86 15167147558
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.