Intratumoral injection of GM103 for advanced solid tumors

A Phase I/II, Open-label, Dose-escalation With Expansion Study of GM103 Via Intratumoral Injection, Alone and in Combination With Pembrolizumab in Adult Patients With Locally Advanced, Unresectable, Refractory and/or Metastatic Solid Tumors

This study is testing a new virus treatment called GM103, alone and with another drug, to see if it can help people with advanced solid tumors that are hard to treat.

Quick facts

• Phase: Phase1; Phase2
• Study type: Interventional
• Enrollment: 125 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: GeneMedicine Co., Ltd. (Industry-sponsored)
• Drugs / interventions: Radiation, pembrolizumab
• Locations: 4 sites (Goyang-si, Gyeonggi-do and 3 other locations)
• Trial ID: NCT06265025 on ClinicalTrials.gov

What this trial studies

This study evaluates the safety, tolerability, and preliminary anti-tumor efficacy of GM103, an oncolytic virus, administered alone and in combination with pembrolizumab in patients with locally advanced, unresectable, refractory, and/or metastatic solid tumors. The trial is divided into three parts: Part A and B focus on GM103 as a monotherapy, while Part C assesses its efficacy in combination with pembrolizumab. The study aims to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) based on safety profiles and to evaluate anti-tumor responses using imaging techniques. Participants will undergo tumor biopsies and imaging assessments to monitor disease progression and treatment response.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and over with locally advanced, unresectable, refractory, and/or metastatic solid tumors that are accessible for biopsy.

Not a fit: Patients with tumors that are not accessible for injection or those who do not meet the inclusion criteria may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new therapeutic option for patients with difficult-to-treat solid tumors.

How similar studies have performed: Other studies using oncolytic viruses have shown promising results, indicating potential for success with this approach.

Eligibility criteria

Inclusion Criteria:

1. Patient must be 18 years of age or over, at the time of signing the informed consent.
2. Have a diagnosis of locally advanced, unresectable, refractory and/or metastatic solid tumors
3. Have a tumor that is accessible and is willing to consent to tumor biopsies during the study.
4. Have at least one measurable site of disease according to RECIST 1.1 criteria; The lesions should be either previously non irradiated or progressive lesions after irradiation, that can be accurately measured at baseline (for measurable lesions) with computed tomography (CT) or magnetic resonance imaging (MRI).
5. Part A, B and C: Have at least one intratumorally injectable lesion (measurable and/or non-measurable based on RECIST 1.1), that can be accurately measured at baseline (for measurable lesions) with computed tomography (CT) or magnetic resonance imaging (MRI) or positron emission tomography-computed tomography (PET-CT); or clinical examination and which is suitable for repeated measurement.
6. Part B and C (only for dose expansion cohort): Have paired pre- and on treatment tumor biopsies for patients with metastases that are safely accessible as determined by the investigator.
7. Patients with brain metastasis must have stable disease and must be neurologically asymptomatic and not requiring corticosteroid treatment.
8. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1.
9. Have a predicted life expectancy of 12 weeks or more.
10. Able to comply with study procedures in the Investigator's opinion.
11. Adequate organ function determined within 4 weeks prior to screening
12. Patient is male or female.
13. Contraceptive use by women must be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
14. Patient is capable of giving signed informed consent.

Exclusion Criteria:

1. Known history or eiciency virus \[HIV\]/acquired immunodeficiency syndrome \[AIDS\]) and/or medication.
2. Patients with a condition requiring systemic treatment with either corticosteroids (\>10 mg daily prednisolone equivalent) or other immunosuppressive medications within 14 days of the first dose of study treatment.
3. Patients with a history of, or active, known or suspected auto-immune disease or a syndrome that requires systemic or immunosuppressive agents.
4. Active infections requiring antibiotics, physician monitoring or recurrent fevers (\>38.0 ̊C) associated with a clinical diagnosis of active infection.
5. Patient who has a history of seizures, central nervous system abnormalities, mental disorders, and heart disease.
6. Patient who has a history of pleural effusion, pulmonary embolism, and intestinal obstruction.
7. Treatment with any systemic anticancer therapies for locally advanced or metastatic within 4 weeks or 6 half-lives of prior anticancer therapy, whichever is shorter, prior to initiation of study treatment.
8. Previous treated with GM103 or other oncolytic viruses.
9. Radiation therapy within 2 weeks prior to enrollment.
10. Use of the antiviral agents within 7 days prior to the first dose of study treatment; or pegylated interferon in the 14 days before the first dose of study treatment
11. Patients who have received a live vaccine within 30 days of study enrollment.
12. Any serious or uncontrolled medical disorder that, in the opinion of the Investigator or the Medical Monitor, may increase the risk associated with study participation or study treatment administration, impair the ability of the patient to receive protocol therapy or interfere with the interpretation of study results.
13. Participation of any other clinical trials within 4 weeks prior to first administration of study treatment.
14. Administration of an investigational drug in the 28 days before the first dose of study treatment.
15. Has an ejection fraction (EF) of 50% or less, based on a multigated acquisition (MUGA) scan or echocardiogram (ECHO).
16. Major surgery within 4 weeks prior to enrollment.
17. Inability or unwillingness to follow study procedures including drug administration.
18. Any serious medical condition or abnormality in clinical laboratory tests

Where this trial is running

Goyang-si, Gyeonggi-do and 3 other locations

• National Cancer Center — Goyang-si, Gyeonggi-do, South Korea (Not_yet_recruiting)
• Korea University Anam Hospital — Seoul, South Korea (Not_yet_recruiting)
• Hanyang University Seoul Hospital — Seoul, South Korea (Not_yet_recruiting)
• Severance Hospital, Yonsei University Health System — Seoul, South Korea (Recruiting)

Study contacts

• Principal investigator: SH Lee — Korea University Anam Hospital
• Study coordinator: KyoungRyun Park

Conditions Head and Neck Cancer; Malignant Melanoma; Colorectal Cancer; Renal Cell Carcinoma; Cervical Cancer; Breast Cancer; Oncolytic Virus; OV