Intraneural Facilitation and Otago Exercise for Diabetic Peripheral Neuropathy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 50–75 with type 2 diabetes and symptomatic diabetic peripheral neuropathy (DN4 ≥ 4) who can walk at least 10 meters and complete the TUG in under 15 seconds will be enrolled at Rasheed Hospital in Lahore. Participants will receive intraneural facilitation (manual techniques aimed at improving nerve blood flow), the Otago Exercise Program (a structured strength and balance regimen), or both combined, delivered in person. Outcomes will include measures of balance, timed-up-and-go, neuropathic pain scores, and quality-of-life measures collected before and after the intervention period. The trial compares these approaches directly to identify which strategy most effectively reduces fall risk and neuropathic symptoms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 50-75years
* Both male and female patients will be included in the study
* Patient with type 2 diabetes mellitus (diagnosed by the physician)
* Patients with a score ≥ 4 on DN4 scale
* Patients have a score on the Timed Up-and-Go (TUG) test of less than 15 s
* Able to walk at least 10 meters long

Exclusion Criteria:

* Patient with presence of any other systemic disease rather than diabetes such as end-stage renal failure, uncontrolled hypertension, severe dyslipidemia, chronic liver disease, autoimmune disease, advanced chronic obstructive pulmonary disease etc
* Patients with documented active alcohol or drug misuse
* Patient with total or partial amputation of lower extremities
* Participants will be also excluded if they were morbidly obese or if pregnant (self-reported)
* Patient with active inflammations or other inflammatory neuropathies including chronic inflammatory demyelinating polyneuropathy, proximal diabetic neuropathy, chemotherapy-induced peripheral neuropathy, autonomic neuropathies, or other neuropathies not associated with DM such as B12 deficiency

Where it's running

• Rasheed Hospital
  Lahore, Punjab Province, Pakistan Recruiting

Study contacts

• Principal investigator: Aruba Saeed, PhD — Riphah International University
• Study coordinator: Imran Amjad, PhD
• Email: imran.amjad@riphah.edu.pk
• Phone: 03324390125

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.