Intramuscular vs. Intravenous Tranexamic Acid in Total Hip Replacement

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, early-phase study compares intramuscular and intravenous tranexamic acid in adults undergoing elective primary total hip arthroplasty. Participants are randomized to receive TXA by intramuscular injection or by IV administration with the goal of minimizing perioperative blood loss. The study uses standard care protocols and includes safety monitoring for thromboembolic events and other TXA-related risks. Enrollment targets adults 18 years and older who can provide informed consent, excluding those with recent thromboembolic history, kidney issues, or contraindications to TXA. The lead sponsor is Alexandria University, with procedures conducted at Alexandria university main hospitals in Alexandria, Egypt.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult patients aged 18 years and older.
2. Scheduled to undergo elective primary total hip arthroplasty.
3. Able to provide informed consent.

Exclusion Criteria:

* 1\. History of renal failure or kidney transplant. 2. History of an arterial thromboembolic event (such as myocardial infarction or stroke) within the past year.

  3\. Placement of an arterial stent within the past year. 4. History of deep venous thrombosis (DVT) or pulmonary embolism (PE). 5. Known contraindications to tranexamic acid. 6. Pregnancy or breastfeeding. 7. Refusal to participate or refusal to consent to receive blood products.

Where it's running

• Alexandria university main hospitals
  Alexandria, Egypt Recruiting

Study contacts

• Study coordinator: Tarek I Ismail
• Email: Drtarek.anesth@gmail.com
• Phone: +201001467166

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.