Primary anastomosis vs Bishop-Koop for neonatal jejunoileal atresia
Official title: A Prospective Randomized Controlled Trial Comparing Primary Anastomosis and Bishop-Koop Procedure in the Management of Jejunoileal Atresia in Neonates
Run by Alexandria University · NCT07925814 · Data updated 2026-11-12
This study tests whether primary anastomosis or a Bishop-Koop procedure better supports recovery in newborns with jejunoileal atresia.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | Any age to 28 Days |
| Sex | All |
| Enrollment | 52 (estimated) |
| Sponsor | Alexandria University Academic / other |
| Locations | 1 site (Alexandria) |
| Status | Recruiting |
| Started | May 1, 2026 |
| Main results expected | January 1, 2028 |
| Study ends | May 30, 2028 |
| Registry record updated | November 9, 2026 |
| Trial ID | NCT07925814 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Neonates diagnosed intraoperatively with jejunal or ileal atresia, aged 28 days or younger, who are hemodynamically stable and do not have gross bowel necrosis or weight ≤ 2.5 kg.
✕Probably not a fit
Neonates with major life-limiting congenital anomalies, low birth weight (<2.5 kg) or unstable condition may not benefit from these procedures within the trial.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective randomized controlled trial compares two surgical approaches for neonatal jejunoileal atresia: primary anastomosis with or without tapering versus Bishop-Koop. Eligible neonates (≤28 days old, stable, no extensive bowel necrosis) are randomized 1:1 and stratified by jejunal versus ileal atresia. Data collected include operative details, early postoperative outcomes, time to feeding, bowel function, imaging before discharge, length of hospital stay, need for re-exploration, 30-day mortality, and 3–6 month follow-up. The study is conducted at Alexandria University Hospital, with enrollment planned from January 2026 to January 2028. Outcomes will inform which technique offers safer recovery and better short- to mid-term bowel function.
Why it matters
Potential benefit: If successful, the trial could identify the preferred surgical approach to improve recovery and reduce complications for newborns with jejunoileal atresia.
How similar studies have gone: Previous work in neonatal intestinal atresia has explored similar surgical options, but this specific randomized comparison has limited prior data and results are therefore not definitive.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Neonates diagnosed intraoperatively with jejunal or ileal atresia * Age ≤ 28 days * Hemodynamically stable * No gross bowel necrosis requiring extensive resection Exclusion Criteria: * Major life-limiting congenital anomalies * Weight ≤ 2.5 kg
Where it's running
-
Alexandria University Faculty of Medicine
Alexandria, Egypt Recruiting
Study contacts
- Principal investigator: Ahmed Maher Khalil, lecturer of pediatric surgery — Alexandria University
- Study coordinator: Dr. Ahmed Maher Fathy Mohamed Khalil, lecturer of pediatric surgery
- Email: ahmed.maher@alexmed.edu.eg
- Phone: +201128087844
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.