Internet-based cognitive behavioral therapy for depression in older adults

Community-Embedded, Layperson-Supported Digital Mental Health Intervention for Homebound Older Adults With Depression: A Type 1 Hybrid Effectiveness- Implementation RCT

Not applicable Interventional University of Michigan · NCT06584422

This study is testing an online therapy program to see if it can help older adults who are stuck at home and feeling depressed feel better compared to regular care.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment256 (estimated)
Ages50 Years and up
SexAll
SponsorUniversity of Michigan Academic / other
Locations1 site (Ann Arbor, Michigan)
Trial IDNCT06584422 on ClinicalTrials.gov

What this trial studies

This trial evaluates the effectiveness of Empower@Home, an internet-delivered cognitive-behavioral therapy (CBT) program, for homebound older adults experiencing depressive symptoms. A total of 256 participants will be randomly assigned to either the Empower@Home program or enhanced usual care, with the aim of assessing improvements in depressive symptoms over 12, 24, and 36 weeks. The study also explores treatment moderators and conducts a cost-effectiveness analysis to determine the economic viability of the intervention. By leveraging aging service providers, the program addresses barriers to accessing traditional mental health services faced by this population.

Who should consider this trial

Good fit: Ideal candidates are homebound older adults aged 50 and above who have moderate depressive symptoms and are eligible for services at the recruitment sites.

Not a fit: Patients with probable dementia, high suicide risk, or severe physical health issues may not benefit from this study.

Why it matters

Potential benefit: If successful, this program could significantly improve mental health outcomes for homebound older adults suffering from depression.

How similar studies have performed: Other studies have shown promise with internet-based CBT interventions for depression, indicating potential success for this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* (1) be receiving or eligible to receive services at the recruitment sites
* (2) read and speak English
* (3) be at least 50 years old
* (4) have at least moderate depressive symptoms at screening (≥ 8 on the Patient Health Questionnaire-9 \[PHQ-9\]).
* (5) Participants who are NOT currently receiving outside therapy must agree NOT to start outside therapy during study participation. Participants who are currently receiving outside therapy must agree NOT to increase their outside therapy frequency during study participation.

Exclusion Criteria:

* (1) probable dementia based on the Blessed Orientation and Memory Scale.
* (2) moderate or high risk of suicide based on the 6-item Columbia-Suicide Severity Rating Scale
* (3) a terminal illness with less than six months to live or unstable physical health conditions based on self-report
* (4) a diagnosis of a psychotic disorder like schizophrenia or bipolar disorder based on self-report and medical chart review
* (5) severe vision impairment based on self-report (i.e., legally blind)
* (6) current substance use disorders or receiving substance use treatment.
* (7) currently receiving outside therapy more frequently than once a month or have started a new therapy treatment less than 3 months ago

Where this trial is running

Ann Arbor, Michigan

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions DepressionCognitive behavioral therapyOlder AdultsInternet-based interventionSocial isolation
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.