International registry for patients with retroperitoneal sarcoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This initiative aims to prospectively collect standardized clinical data and biological samples from patients with primary retroperitoneal sarcoma (RPS) who undergo surgical treatment at specialized centers. The study will evaluate patient outcomes, including overall survival and disease-free survival, while also assessing the efficacy and safety of surgical interventions and multimodal therapies like chemotherapy and radiation. By focusing on a rare disease with high local recurrence rates, the study seeks to enhance understanding and treatment approaches for RPS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* primary RPS operated on in the participating center;
* age\>18 years at the time of the first treatment (pediatric patients can not be included)
* histological confirmed diagnosis according to the WHO criteria done on biopsy or surgical specimen by dedicated sarcoma pathologist;
* radiological examinations performed (contrast enhanced abdominal CT scan and/or MRI) prior to surgical resection;
* signed informed consent form;
* adequate compliance of the patients to the plan of follow-up

Exclusion Criteria:

* age\<18 years;
* recurrent tumor;
* benign retroperitoneal tumors;
* serious psychiatric disease that precludes informed consent or limits compliance;
* impossibility to ensure adequate follow-up

Where it's running

• University of Southern California (USC)
  Los Angeles, California, United States Recruiting
• Mayo Clinic
  Jacksonville, Florida, United States Recruiting
• Moffitt Cancer Center
  Tampa, Florida, United States Recruiting
• Winship Cancer Institute
  Emory, Georgia, United States Recruiting
• Brigham and Women's Hospital/Dana-Farber Cancer Institute
  Boston, Massachusetts, United States Recruiting
• The Ohio State University
  Columbus, Ohio, United States Recruiting

Study contacts

• Principal investigator: Alessandro Gronchi, MD — Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
• Study coordinator: Alessandro Gronchi, MD
• Email: alessandro.gronchi@istitutotumori.mi.it
• Phone: +39022390

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Personalised neoadjuvant therapy planning for adults with high‑risk soft tissue sarcoma

  This project tests whether analyzing tumor tissue and clinical data can help guide neoadjuvant chemotherapy decisions for adults with high‑risk soft tissue sarcomas.

  Recruiting Royal Marsden NHS Foundation Trust · London · NCT07432932

• Assessing colorectal resections in patients with retroperitoneal sarcoma

  This study is trying to see how different surgical techniques for removing retroperitoneal sarcomas affect patients' recovery and quality of life.

  Recruiting at 16 sites Heidelberg University · Mannheim, Baden-Wurttemberg and 15 other locations · NCT06943612

• Short course radiation treatment for retroperitoneal sarcoma before surgery

  This study is testing a shorter radiation treatment for patients with retroperitoneal sarcoma to see if it can be safely used before surgery.

  Recruiting Phase 1 Brigham and Women's Hospital · Boston, Massachusetts · NCT06812052

• Electrochemotherapy for unresectable visceral tumors including liver metastases

  This will try electrochemotherapy with bleomycin in adults who have unresectable primary or metastatic visceral tumors, such as liver metastases.

  Recruiting Istituto Oncologico Veneto IRCCS · Padova · NCT06753136

• Proton therapy combined with standard radiation for treating retroperitoneal sarcoma

  This study is testing a new type of radiation therapy combined with standard treatment to see if it helps people with newly diagnosed retroperitoneal sarcoma before they have surgery.

  Recruiting Phase 1/2 Northwestern University · Chicago, Illinois · NCT06327477

• Using Abemaciclib and Radiation Therapy Before Surgery for High-Risk Retroperitoneal Sarcoma

  This study is testing if taking a medication called abemaciclib along with radiation therapy before surgery can help shrink tumors in patients with high-risk retroperitoneal sarcoma.

  Recruiting Phase 1 University of Washington · Seattle, Washington · NCT06025747

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.