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International registry for patients with retroperitoneal sarcoma

REtroperitoneal SArcoma Registry (RESAR): Prospective Collection of Primary Retroperitoneal Sarcoma Patient's Data, Radiological and Pathological Material for the TransAtlantic Retroperitoneal Sarcoma Working Group

Observational Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · NCT03838718

This study is collecting information and samples from patients with retroperitoneal sarcoma who have surgery to see how well different treatments work and how they affect survival.

Quick facts

Study typeObservational
Enrollment2000 (estimated)
Ages18 Years and up
SexAll
SponsorFondazione IRCCS Istituto Nazionale dei Tumori, Milano Academic / other
Drugs / interventionschemotherapy, radiation
Locations22 sites (Los Angeles, California and 21 other locations)
Trial IDNCT03838718 on ClinicalTrials.gov

What this trial studies

This initiative aims to prospectively collect standardized clinical data and biological samples from patients with primary retroperitoneal sarcoma (RPS) who undergo surgical treatment at specialized centers. The study will evaluate patient outcomes, including overall survival and disease-free survival, while also assessing the efficacy and safety of surgical interventions and multimodal therapies like chemotherapy and radiation. By focusing on a rare disease with high local recurrence rates, the study seeks to enhance understanding and treatment approaches for RPS.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 years old with a histologically confirmed diagnosis of primary retroperitoneal sarcoma who are undergoing surgical treatment.

Not a fit: Patients with recurrent tumors, benign retroperitoneal tumors, or those under 18 years old may not benefit from this study.

Why it matters

Potential benefit: If successful, this initiative could lead to improved treatment strategies and outcomes for patients with retroperitoneal sarcoma.

How similar studies have performed: While there have been retrospective studies on retroperitoneal sarcoma, this prospective approach is relatively novel and aims to fill gaps in existing research.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* primary RPS operated on in the participating center;
* age\>18 years at the time of the first treatment (pediatric patients can not be included)
* histological confirmed diagnosis according to the WHO criteria done on biopsy or surgical specimen by dedicated sarcoma pathologist;
* radiological examinations performed (contrast enhanced abdominal CT scan and/or MRI) prior to surgical resection;
* signed informed consent form;
* adequate compliance of the patients to the plan of follow-up

Exclusion Criteria:

* age\<18 years;
* recurrent tumor;
* benign retroperitoneal tumors;
* serious psychiatric disease that precludes informed consent or limits compliance;
* impossibility to ensure adequate follow-up

Where this trial is running

Los Angeles, California and 21 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Retroperitoneal SarcomaSarcomaSurgeryMultivisceral resectionChemotherapyRadiation TherapyPatients' Registry
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.