Inter-Limb Transfer after Acute Stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study investigates if motor skill learning using rehabilitation robots can transfer benefits from the ipsilesional upper limb to the contralesional limb in acute and subacute stroke, as well as in healthy controls. Participants perform proximal and distal motor tasks using the REAplan robotic system and the Dextrain Manipulandum, with some groups receiving three days of training and others only assessments. Behavioral measures and multimodal MRI, including diffusion imaging and lesion mapping, are used to explore neural substrates of inter-limb transfer. The study includes randomized groups across healthy individuals, acute stroke patients, and chronic stroke patients, with imaging-based analyses to relate brain structure to observed transfer effects.

Why it matters

Who can join: the full rules

ACUTE STROKE PATIENTS:

Inclusion Criteria:

* First acute ischemic or hemorrhagic stroke
* Between the 2nd and 21st day post-stroke
* Age: 40-90 years
* Ability to complete the 3 consecutive sessions

Exclusion Criteria:

* Stroke with multiple brain lesions
* Addiction (e.g., alcohol or drugs)
* Pregnancy
* Major cognitive impairment (e.g., depression, aphasia, dementia)
* Inability to perform or understand the required tasks
* Uncontrolled health conditions
* " classical " contre-indication to MRI (non-MR-compatible pacemaker, pregnancy, non-MR-compatible implanted devices, claustrophobia, etc ...)

HEALTHY INDIVIDUALS:

Inclusion Criteria:

* 40-90 years
* availability to complete three consecutive sessions.

Exclusion Criteria:

* "classical" contre-indication to MRI (non-MR-compatible pacemaker, pregnancy, non-MR-compatible implanted devices, claustrophobia, etc ...)
* medical history with a previous stroke/relevant neurological deficit or disease
* drug/alcohol abuse
* psychiatric condition/dementia
* having already used the robotic devices

CHRONIC STROKE PATIENTS:

Inclusion Criteria:

* single stroke confirmed by brain imaging
* time since stroke onset \>6 months
* age between 40-90 years
* availability to complete three consecutive sessions.

Exclusion Criteria:

* Stroke with multiple brain lesions
* Addiction (e.g., alcohol or drugs)
* Pregnancy
* Major cognitive impairment (e.g., depression, aphasia, dementia)
* Inability to perform or understand the required tasks
* Uncontrolled health conditions
* having already used the robotic devices

Where it's running

• CHU UCL Namur
  Yvoir, Namur, Belgium Recruiting
• Cliniques universitaires Saint-Luc
  Brussels, Belgium Recruiting

Study contacts

• Principal investigator: Yves Vandermeeren, MD,PhD — UCLouvain IONS
• Study coordinator: Yves Vandermeeren, MD, PhD
• Email: yves.vandermeeren@uclouvain.be
• Phone: +32 81 42 33 21

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Unimanual vs. Bimanual Motor Skill Learning After Stroke

  The study tests whether people with acute or chronic stroke, as well as healthy controls, can learn and remember a complex motor task using one hand or both, with robotic devices REAplan and Dextrain.

  Recruiting University Hospital of Mont-Godinne · Yvoir, Namur · NCT07826832

• Effectiveness of a new neurorehabilitation technology for stroke recovery

  This study is testing a new rehabilitation technology that uses robots and virtual reality to see if it can help stroke patients recover better than regular therapy.

  Recruiting Neurotechnika · Samara, Samara Oblast · NCT06753006

• Using the Atalante exoskeleton to help stroke patients walk again

  This study is testing if using the Atalante exoskeleton can help stroke patients walk better compared to regular therapy.

  Recruiting at 4 sites Wandercraft · Créteil and 4 other locations · NCT06107010

• Bimanual motor skill learning for patients recovering from acute stroke

  This study tests how stroke affects learning to use both hands together and aims to find better ways to help patients recover their motor skills.

  Recruiting at 2 sites University Hospital of Mont-Godinne · Yvoir, Namur and 1 other locations · NCT05760846

• Music therapy after stroke

  This trial tests whether adding music therapy to standard care helps stroke patients sleep better and feel less anxious or depressed while in the hospital.

  Recruiting Universidad de Granada · Granada, Granada · NCT07899034

• Endovascular therapy plus standard care vs standard care alone for distal and medium vessel strokes

  In people with acute ischemic stroke due to distal or medium vessel blockages, this study tests whether adding endovascular treatment to the usual medical care helps improve outcomes compared with medical care alone.

  Recruiting Hospital Universitari Vall d'Hebron Research Institute · Barcelona, Barcelona · NCT07843797

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.