Intensive rehab plus tendon vibration to improve balance in adults with CMT1A

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with genetically confirmed CMT1A will undergo an intensive, multidisciplinary rehabilitation program that may include strength, balance, and gait training, together with tendon vibratory stimulation. The study aims to see if this combination improves balance and reduces falls compared with baseline expectations. Eligible participants are 18 to 65 years old with a specific level of lower-limb impairment and no other major conditions that cause neuropathy. The trial will be conducted at a Marseille-based center under the lead sponsor UGECAM PACA et Corse. Results could inform standardized rehabilitation strategies for CMT1A.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals with genetically confirmed Charcot-Marie-Tooth disease type 1A (CMT1A), characterized by PMP22 gene duplication on chromosome 17 (17p11.2).
* Age between 18 and 65 years.
* Overall Neuropathy Limitations Scale (ONLS) score between 2 and 3/7 for the lower limbs.
* Affiliation with a social security/health insurance system.
* Written informed consent voluntarily provided after receiving information regarding the study objectives, procedures, and potential risks.

Exclusion Criteria:

* Comorbidities causing peripheral neuropathy (e.g., diabetes, renal failure, medication-induced neuropathy).
* Balance or gait disorders due to another cause.
* Individuals without a permanent residence.
* Individuals deprived of liberty by judicial or administrative decision or under legal guardianship.
* Individuals unable to understand the study objectives and procedures or unable to provide informed consent.
* Individuals unable to complete all study procedures.
* Previous use of the Vibramoov device.
* Pregnant women or women planning to become pregnant during the study period.
* Concurrent participation in another research study.

Where it's running

• IUR Valmante Sud
  Marseille, France Recruiting

Study contacts

• Study coordinator: Laurent Bensoussan, MD
• Email: laurent.bensoussan@ugecam.assurance-maladie.fr
• Phone: +33 4 91 74 42 00

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.