Tremor in Charcot–Marie–Tooth disease
Official title: Investigation of Tremor in Patients With Charcot-Marie-Tooth Neuropathy
Run by University Medical Center Goettingen · NCT07570459 · Data updated 2026-11-12
Try to characterize tremor in adults with Charcot–Marie–Tooth (CMT) disease using surface electromyography, accelerometers, a clinical exam and questionnaires to see how tremor affects daily life.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | University Medical Center Goettingen Academic / other |
| Locations | 1 site (Göttingen, Lower Saxony) |
| Status | Recruiting |
| Started | July 30, 2024 |
| Main results expected | July 5, 2026 |
| Study ends | October 30, 2026 |
| Registry record updated | May 6, 2026 |
| Trial ID | NCT07570459 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 with a clinical diagnosis and genetic confirmation of CMT who can complete EMG/accelerometer testing, undergo the clinical exam, and provide informed consent (healthy controls may be enrolled as comparators).
✕Probably not a fit
People who are pregnant or breastfeeding, have other relevant neurological or psychiatric disorders, serious internal diseases, or who cannot complete baseline testing or consent are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational project enrolls adults with clinically and genetically confirmed CMT alongside an anamnestically healthy control group to provide comparative data. Participants undergo surface electromyography and accelerometer recordings, a standardized clinical examination that is video-recorded, and questionnaire-based assessments of activities of daily living and tremor burden. The collected clinical and electrophysiological data will be used to describe tremor phenotypes and support etiological classification within the CMT population. All procedures are performed at the University Medical Center Göttingen with written informed consent and inclusion limited to ages 18–65.
Why it matters
Potential benefit: If successful, the study could clarify causes and patterns of tremor in CMT and inform more targeted symptom management and future therapeutic research.
How similar studies have gone: Tremor in CMT has been reported in case reports and small series, but few prior studies have applied systematic surface-EMG and accelerometer characterization, so this approach is partly novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical CMT Diagnosis / Anamnestically Healthy Control Group * Genetic confirmation of CMT in adult patients * Ability to achieve the outcome measure at baseline * Age between 18 and 65 years * Capacity of all study participants to consent and signed informed consent, including patient or participant information and consent form Exclusion Criteria: * Pregnancy or breastfeeding period * Other relevant neurological or psychiatric disorders, acute or in the past history * Presence of a serious previous internal disease
Where it's running
-
University Medical Centre
Göttingen, Lower Saxony, Germany Recruiting
Study contacts
- Study coordinator: Michael W Sereda, Prof. MD
- Email: sereda@mpinat.mpg.de
- Phone: +49 551 3964162
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.