Tremor in Charcot–Marie–Tooth disease
Investigation of Tremor in Patients With Charcot-Marie-Tooth Neuropathy
University Medical Center Goettingen · NCT07570459
Try to characterize tremor in adults with Charcot–Marie–Tooth (CMT) disease using surface electromyography, accelerometers, a clinical exam and questionnaires to see how tremor affects daily life.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 75 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | University Medical Center Goettingen (other) |
| Locations | 1 site (Göttingen, Lower Saxony) |
| Trial ID | NCT07570459 on ClinicalTrials.gov |
What this trial studies
This observational project enrolls adults with clinically and genetically confirmed CMT alongside an anamnestically healthy control group to provide comparative data. Participants undergo surface electromyography and accelerometer recordings, a standardized clinical examination that is video-recorded, and questionnaire-based assessments of activities of daily living and tremor burden. The collected clinical and electrophysiological data will be used to describe tremor phenotypes and support etiological classification within the CMT population. All procedures are performed at the University Medical Center Göttingen with written informed consent and inclusion limited to ages 18–65.
Who should consider this trial
Good fit: Adults aged 18–65 with a clinical diagnosis and genetic confirmation of CMT who can complete EMG/accelerometer testing, undergo the clinical exam, and provide informed consent (healthy controls may be enrolled as comparators).
Not a fit: People who are pregnant or breastfeeding, have other relevant neurological or psychiatric disorders, serious internal diseases, or who cannot complete baseline testing or consent are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the study could clarify causes and patterns of tremor in CMT and inform more targeted symptom management and future therapeutic research.
How similar studies have performed: Tremor in CMT has been reported in case reports and small series, but few prior studies have applied systematic surface-EMG and accelerometer characterization, so this approach is partly novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical CMT Diagnosis / Anamnestically Healthy Control Group * Genetic confirmation of CMT in adult patients * Ability to achieve the outcome measure at baseline * Age between 18 and 65 years * Capacity of all study participants to consent and signed informed consent, including patient or participant information and consent form Exclusion Criteria: * Pregnancy or breastfeeding period * Other relevant neurological or psychiatric disorders, acute or in the past history * Presence of a serious previous internal disease
Where this trial is running
Göttingen, Lower Saxony
- University Medical Centre — Göttingen, Lower Saxony, Germany (RECRUITING)
Study contacts
- Study coordinator: Michael W Sereda, Prof. MD
- Email: sereda@mpinat.mpg.de
- Phone: +49 551 3964162
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: CMT, Charcot Marie Tooth Disease, Tremor in CMT