Integrated trunk stabilization with knee-spine rehabilitation for knee osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study investigates whether incorporating trunk stabilization exercises into conventional knee rehabilitation improves outcomes for adults with knee-spine syndrome and knee osteoarthritis. Participants receive trunk-focused exercises alongside usual rehabilitation, with the aim of enhancing trunk stability to positively affect knee joint mechanics. The study focuses on adults aged 40–60 with bilateral knee OA (Kellgren-Lawrence grades 2–3) and a history of back pain, evaluating pain, mobility and functional performance. It analyzes whether addressing spinal stability can produce meaningful improvements in knee pain and overall function. Findings could support a more integrated rehabilitation approach for knee and spine involvement in OA.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 40-60 years
* Both Genders
* Bilateral Knee osteoarthritis diagnosed according to the American College of Rheumatology Clinical Classification system
* Kellgren \& Lawrence grade 2 and 3 with complaint of pain, crepitations, stiffness and bony enlargement
* History of backpain for the past 3 months with no complaint of radiating pain
* Able to walk independently/unaided

Exclusion Criteria:

* Kellgren \& Lawrence grade 4
* Intra-articular corticosteroid injections in the last 3 months or hyaluronic knee injection in the previous 6 months.
* History of lower limb or lumbar trauma/surgery, presence of fracture or deformity, or planned surgery within the study period
* Lumbar pathologies, for example, spondylolisthesis, ankylosing spondylitis, or any diagnosed severe cardiovascular, pulmonary, neurological, or psychological disease or impairment except lumbar spondylosis
* BMI\>30
* Presence of infection, cauda equina syndrome, or meningitis

Where it's running

• Bahria Active Hospital
  Islamabad, Al, Pakistan Recruiting
• Bahria Active
  Rawalpindi, Pakistan Not yet recruiting

Study contacts

• Principal investigator: Suman Sheraz, PhD — Riphah International University
• Study coordinator: Suman Sheraz, PhD
• Email: suman.sheraz@riphah.edu.pk
• Phone: 03335646361

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Effects of virtual reality on walking in adults with knee osteoarthritis

  This study tests how immersive virtual reality environments—designed to feel safe or to provoke fear—affect walking and worry about movement in adults 50 and older with knee osteoarthritis and in healthy peers.

  Recruiting University of Primorska · Vilnius and 1 other locations · NCT07920120

• Weekly berobenatide for knee osteoarthritis in adults who are overweight or obese

  This study tests whether weekly berobenatide helps reduce knee pain and improve function, while also affecting body weight, in adults with knee osteoarthritis who are overweight or obese (with or without type 2 diabetes).

  Recruiting Phase 3 Pfizer · Birmingham, Alabama and 3 other locations · NCT07915609

• Autologous adipose-derived stem cell injections for knee osteoarthritis

  We’re testing whether injecting a patient’s own fat-derived stem cells into the knee can help people with knee OA feel less pain and move better, compared with a standard hyaluronic acid treatment.

  Recruiting at 3 sites Yonsei University · Incheon and 2 other locations · NCT07901790

• Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty

  This study tests whether higher burden of preoperative multimorbidity affects functional recovery after knee replacement in adults with knee osteoarthritis.

  Recruiting Balikesir Ataturk City Hospital · Balıkesir · NCT07882316

• Cartilage biomarker response to acute loading in knee OA by antiresorptive treatment status

  Researchers will test whether a 30-minute treadmill walk changes cartilage biomarkers in postmenopausal women with knee osteoarthritis, comparing those on denosumab, bisphosphonates, and those not on antiresorptives.

  Recruiting Sisli Hamidiye Etfal Training and Research Hospital · Istanbul, Istanbul · NCT07881861

• Lysyl Enzymes in Knee Osteoarthritis

  This study tests whether blood levels of lysyl hydroxylase and lysyl oxidase differ between people with knee osteoarthritis and healthy individuals.

  Recruiting Afyonkarahisar Health Sciences University · Afyonkarahisar · NCT07875296

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.