Innovative blood tests for ovarian cancer detection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multisite study evaluates investigational liquid biopsy biomarker assays for ovarian cancer, using blood samples from women with EOC and healthy controls. It compares test results to standard blood tests and genetic data to understand relationships with cancer. The design is observational with no randomization or interventions beyond blood collection. Participants include patients with suspected ovarian cancer undergoing surgery or biopsy and healthy controls, with tissue diagnosis used for classification where applicable.

Why it matters

Who can join: the full rules

Inclusion Criteria:

EOC patients

1. Women, trans men and non-binary people with female reproductive organs
2. Aged ≥35 years\*
3. Pathologically diagnosed, by biopsy, with EOC prior to surgical intervention or treatment
4. Presenting with adnexal mass suspicious of OC on imaging and scheduled for surgical resection or biopsy (and subsequent confirmation of EOC)
5. Able to give informed consent

Healthy controls

1. Women, trans men and non-binary people with female reproductive organs
2. Aged ≥35 years
3. No cancer history
4. Able to give informed consent

Exclusion Criteria:

1. Prior history and any treatment for malignancy
2. Prior removal of either ovary for any reason
3. Pregnant or lactating
4. Any condition or circumstance that, in the opinion of the investigator, could interfere with the participant's ability to participate or comply with study requirements

Where it's running

• Vseobecna Fakultni Nemocnice V Praze
  Prague, Czechia Recruiting
• Fakultni Nemocnice Bulovka
  Prague, Czechia Recruiting
• National Centre for Scientific Research Demokritos
  Athens, Attica, Greece Recruiting
• Dept of Clinical Therapeutics, Alexandra Hospital
  Athens, Greece Recruiting
• Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E.
  Lisbon, Portugal Recruiting
• Imperial College Healthcare NHS Trust Hammersmith Hospital
  London, United Kingdom Recruiting

Study contacts

• Study coordinator: Michael Liontos
• Email: mlionto@med.uoa.gr
• Phone: +302132162845

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• CG-7321: a first-in-human test in advanced solid tumors

  We’re testing CG-7321 alone and with fulvestrant to see if it’s safe and tolerable in adults with advanced solid tumors.

  Recruiting at 4 sites Phase 1 Chengdu Cynogen Bio-pharmaceutical Tech. Co., Ltd. · Fuzhou, Fujian and 3 other locations · NCT07923214

• CR-002 study in adults with advanced solid tumors

  This trial tests CR-002 as a single therapy to see if it is safe and tolerable in adults with locally advanced or metastatic solid tumors

  Recruiting at 3 sites Phase 1/2 Crescent Biopharma, Inc. · Austin, Texas and 2 other locations · NCT07909031

• VT-101 in Advanced Ovarian Cancer: early safety study in adults

  This early-phase trial tests VT-101 in adult women with advanced, recurrent, or relapsed epithelial ovarian cancer to see if it is safe, how the body handles it, and whether there are any initial signs of activity.

  Recruiting Phase 1 University of Iowa · Iowa City, Iowa · NCT07905677

• Methylation markers in self-samples to help detect gynecological cancers

  This study tests whether self-collected urine and vaginal samples can reveal DNA methylation or other genetic markers that indicate endometrial, ovarian, vulvar, or vaginal cancers in women who are at risk or have postmenopausal bleeding.

  Recruiting Universiteit Antwerpen · Edegem, Antwerp · NCT07902375

• Radiotherapy for gynecologic cancer with up to 10 metastatic sites

  This registry follows adults with gynecologic cancer who have 1 to 10 active metastatic lesions and are treated with radiotherapy as part of routine care to see how such treatments work in real-world settings.

  Recruiting Affidea Nu-med Center of Oncological DIagnostics and Therapy · Zamość · NCT07883798

• EHR-based approach to boost HBOC genetic testing in at-risk women

  A new EHR tool-based program tests whether computer prompts and real patient resources can help more women with family histories of breast or ovarian cancer get HBOC genetic testing.

  Recruiting Columbia University · New York, New York · NCT07876349

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.