Infusion of selected stem cells to improve graft function in blood cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial focuses on patients who have experienced graft failure or delayed engraftment following allogeneic hematopoietic stem cell transplantation for hematologic malignancies. The study aims to evaluate the safety and efficacy of infusing CD34 selected hematopoietic stem cells using the automated CliniMACS Prodigy system, which streamlines the processing of stem cells. By avoiding standard immune suppression strategies, the trial seeks to reduce the risk of graft versus host disease in these patients. Eligible participants include those with acute myeloid leukemia, acute lymphoblastic leukemia, lymphoid malignancies, myelodysplastic syndromes, and chronic myeloid leukemia who require a stem cell boost.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. AML in morphologic remission with intermediate/high-risk features or relapsed disease 1 or 2
2. ALL in morphologic remission with high-risk features or relapsed disease 1 or 2
3. Lymphoid malignancies in CR or PR (e.g. non-Hodgkin's lymphoma, prolymphocytic leukemia, CLL)
4. Myelodysplastic syndromes with \<=10% blasts
5. CML in morphologic remission after blast phase or accelerated phase
6. Primary myelofibrosis with \<=10% blasts \^morphologic remission is defined as \<5% blasts on the bone marrow biopsy. Negative test for donor-specific antibody within 28 days of starting conditioning regimen, or adequate for standard desensitization protocol.

Exclusion Criteria:

1. Non-compliant patients.
2. No appropriate caregivers identified.
3. Uncontrolled medical or psychiatric disorders which may preclude patients to undergo clinical studies (Discretion of the attending physician).
4. Patients with known allergy to DMSO.
5. Pregnant or breastfeeding women

Where it's running

• University of Alabama at Birmingham
  Birmingham, Alabama, United States Recruiting

Study contacts

• Study coordinator: Antonio Di Stasi, M.D.
• Email: adistasi@uab.edu
• Phone: 205-934-2636

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.