Infusion of Norepinephrine and Phenylephrine for Preeclampsia During Cesarean Section
Official title: Comparison of Prophylactic Norepinephrine and Phenylephrine Infusion for Hemodynamic Effects in Patients With Preeclampsia During Cesarean Section: a Randomized, Controlled Trial
Run by General Hospital of Ningxia Medical University · NCT05035498 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing if giving norepinephrine and phenylephrine during a C-section can help women with preeclampsia maintain stable blood pressure and improve blood flow to the placenta.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 72 (estimated) |
| Sponsor | General Hospital of Ningxia Medical University Academic / other |
| Locations | 1 site (Yinchuan, Ningxia) |
| Trial ID | NCT05035498 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18-45 with singleton pregnancies of at least 32 weeks scheduled for cesarean section under spinal anesthesia.
✕Probably not a fit
Patients with severe hypertension, eclampsia, or significant fetal distress may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of prophylactic norepinephrine and phenylephrine infusion on maternal cardiac output in patients with preeclampsia undergoing cesarean section under spinal anesthesia. Preeclampsia, affecting 5% to 7% of pregnant women, can lead to significant complications, including maternal and neonatal morbidity. The research aims to determine if these infusions can prevent postspinal anesthesia hypotension, which occurs in a notable percentage of preeclamptic patients. By improving hemodynamic stability, the study seeks to enhance placental perfusion during surgery.
Why it matters
Potential benefit: If successful, this approach could significantly improve maternal and neonatal outcomes during cesarean sections for patients with preeclampsia.
How similar studies have gone: While the use of norepinephrine in this context is gaining traction, the specific hemodynamic effects of prophylactic infusion in preeclamptic patients remain largely untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-45 years * Primipara or multipara * Singleton pregnancy ≥32 weeks * American Society of Anesthesiologists physical status classification II to III * Scheduled for cesarean section under spinal anesthesia Exclusion Criteria: * Baseline blood pressure ≥180 mmHg * Body height \< 150 cm * Body weight \> 100 kg or body mass index (BMI) ≥ 40 kg/m2 * Eclampsia or chronic hypertension * Hemoglobin \< 7g/dl * Fetal distress, or known fetal developmental anomaly
Where it's running
-
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China Recruiting
Study contacts
- Study coordinator: Xinli Ni, Dr.
- Email: xinlini6@nyfy.com.cn
- Phone: 86-951-674-3252
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.