Infusion of Norepinephrine and Phenylephrine for Preeclampsia During Cesarean Section
Comparison of Prophylactic Norepinephrine and Phenylephrine Infusion for Hemodynamic Effects in Patients With Preeclampsia During Cesarean Section: a Randomized, Controlled Trial
This study is testing if giving norepinephrine and phenylephrine during a C-section can help women with preeclampsia maintain stable blood pressure and improve blood flow to the placenta.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 72 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | General Hospital of Ningxia Medical University Academic / other |
| Locations | 1 site (Yinchuan, Ningxia) |
| Trial ID | NCT05035498 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of prophylactic norepinephrine and phenylephrine infusion on maternal cardiac output in patients with preeclampsia undergoing cesarean section under spinal anesthesia. Preeclampsia, affecting 5% to 7% of pregnant women, can lead to significant complications, including maternal and neonatal morbidity. The research aims to determine if these infusions can prevent postspinal anesthesia hypotension, which occurs in a notable percentage of preeclamptic patients. By improving hemodynamic stability, the study seeks to enhance placental perfusion during surgery.
Who should consider this trial
Good fit: Ideal candidates are women aged 18-45 with singleton pregnancies of at least 32 weeks scheduled for cesarean section under spinal anesthesia.
Not a fit: Patients with severe hypertension, eclampsia, or significant fetal distress may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve maternal and neonatal outcomes during cesarean sections for patients with preeclampsia.
How similar studies have performed: While the use of norepinephrine in this context is gaining traction, the specific hemodynamic effects of prophylactic infusion in preeclamptic patients remain largely untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-45 years * Primipara or multipara * Singleton pregnancy ≥32 weeks * American Society of Anesthesiologists physical status classification II to III * Scheduled for cesarean section under spinal anesthesia Exclusion Criteria: * Baseline blood pressure ≥180 mmHg * Body height \< 150 cm * Body weight \> 100 kg or body mass index (BMI) ≥ 40 kg/m2 * Eclampsia or chronic hypertension * Hemoglobin \< 7g/dl * Fetal distress, or known fetal developmental anomaly
Where this trial is running
Yinchuan, Ningxia
- General Hospital of Ningxia Medical University — Yinchuan, Ningxia, China (Recruiting)
Study contacts
- Study coordinator: Xinli Ni, Dr.
- Email: xinlini6@nyfy.com.cn
- Phone: 86-951-674-3252
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.