Infiltration with ropivacaine plus triamcinolone to relieve pain after VATS surgery
Official title: The Efficacy and Safety of Pre-incisional Infiltration With Ropivacaine Plus Triamcinolone in Patients Undergoing Video-assisted Thoracoscopic: a Multi-center Randomized Controlled Trial.
Run by Beijing Tiantan Hospital · NCT07603921 · Data updated 2026-11-12
This study tests whether injecting ropivacaine with or without triamcinolone before incision can reduce pain after thoracoscopic lung surgery in adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 64 Years |
| Sex | All |
| Enrollment | 346 (estimated) |
| Sponsor | Beijing Tiantan Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | September 1, 2026 |
| Main results expected | May 31, 2027 |
| Study ends | March 31, 2028 |
| Registry record updated | September 17, 2026 |
| Trial ID | NCT07603921 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18-64 scheduled for elective VATS lung procedures (wedge resection, segmentectomy, or lobectomy) with ASA I–III, able to consent and participate in follow-up.
✕Probably not a fit
Patients who are allergic to opioids, steroids, or local anesthetics, those with significant organ dysfunction, or those unable to complete pain assessments may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study examines pre-incisional infiltration of local anesthetic agents to reduce postoperative pain after video-assisted thoracoscopic surgery for lung procedures. Participants are adults (18-64) undergoing wedge resection, segmentectomy, or lobectomy who are ASA I–III. The trial compares ropivacaine with triamcinolone versus ropivacaine alone, aiming to see if the combination provides superior analgesia and improves recovery. Outcomes focus on pain control in the immediate perioperative period and early postoperative recovery. The study is conducted at Beijing Tiantan Hospital with the aim of informing analgesia practices for VATS procedures.
Why it matters
Potential benefit: If successful, patients may experience less postoperative pain and faster recovery after VATS lung surgery.
How similar studies have gone: Previous approaches using regional/local analgesia for thoracic surgery have shown reduced pain, but this exact combination (ropivacaine plus triamcinolone vs ropivacaine alone) is less established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients scheduled for elective thoracoscopic wedge resection, segmentectomy, and lobectomy under general anesthesia; 2. Ages 18 to 64 years old 3. American Society of Anesthesiologists (ASA) physical status of I-III 4. Patients must be able to understand nature and potential personal consequences of the clinical trial and cooperation with follow-up investigations 5. signing of the informed consent form. Exclusion Criteria: 1. History of allergies to experimental drugs such as opioids or steroids; 2. Alcohol abuse; Long term use of opioid drugs (exceeding 2 weeks or 3 days per week for more than 1 month); Suspected use of sedatives and analgesics; Use analgesic drugs within 24 hours before surgery; Patients undergoing steroid therapy; 3. Serious neurological disorders, severe liver and kidney dysfunction, heart failure, etc; 4. Unable to use pain assessment scale; 5. Pregnant or lactating patients.
Where it's running
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Beijing Tiantan Hospital
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: Fang Luo
- Email: 13611326978@163.com
- Phone: +86 13611326978
Similar studies
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We will test whether adding long‑acting liposomal bupivacaine to a rhomboid intercostal nerve block reduces pain after video‑assisted thoracoscopic lung surgery in adults.
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Liposomal bupivacaine to reduce pain after VATS
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.