Improving self-management in adolescents with sickle cell disease
Official title: A Socio-ecological Approach for Improving Self-management in Adolescents With SCD
Run by Children's Hospital Medical Center, Cincinnati · NCT06290401 · Data updated 2026-11-12
This study is testing a new online program to help teenagers and young adults with sickle cell disease better manage their health and see if it works better than regular care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 13 Years to 21 Years |
| Sex | All |
| Enrollment | 310 (estimated) |
| Sponsor | Children's Hospital Medical Center, Cincinnati Academic / other |
| Locations | 4 sites (Wilmington, Delaware and 3 other locations) |
| Status | Recruiting |
| Started | February 3, 2025 |
| Main results expected | January 31, 2028 |
| Study ends | June 30, 2028 |
| Registry record updated | May 11, 2026 |
| Trial ID | NCT06290401 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adolescents and young adults aged 13-21 with a confirmed diagnosis of sickle cell disease.
✕Probably not a fit
Patients with other chronic diseases, non-English speakers, or those with cognitive or psychiatric disorders may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the SCThrive intervention, a behavioral self-management program designed for adolescents and young adults with sickle cell disease (SCD). Participants aged 13-21 will engage in an 8-week virtual group intervention supported by a mobile app, focusing on enhancing patient activation and self-management behaviors. The study will compare outcomes between those using SCThrive and those receiving standard care, assessing improvements in daily functioning and emergency room visits. Additionally, the research will explore the impact of social determinants of health on treatment response.
Why it matters
Potential benefit: If successful, this intervention could significantly enhance self-management skills and reduce emergency room visits for adolescents with sickle cell disease.
How similar studies have gone: Previous pilot studies have shown promising results with similar behavioral interventions, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient of a participating SCD Clinic * Confirmed diagnosis of SCD * 13-21 years of age Exclusion Criteria: * Another chronic disease (which would complicate measurement of patient activation) * Non-English-speaking * Cognitive or psychiatric disorder that the physician or study therapists believe would impair study participation.
Where it's running
-
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States Recruiting -
Nemours Children's Health
Wilmington, Delaware, United States Not yet recruiting -
Children's Healthcare of Atlanta
Atlanta, Georgia, United States Not yet recruiting -
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States Not yet recruiting
Study contacts
- Principal investigator: Lori E. Crosby, PsyD — Children's Hospital Medical Center, Cincinnati
- Study coordinator: Ama Wilson, MPH
- Email: Ama.Wilson@cchmc.org
- Phone: 15136365380
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.