Clinical trial Recruiting at 1 site Interventional Ages 65 and up

Improving physical performance in older hospitalized patients through personalized nutrition and exercise

Official title: The Effect of a Combined Personalized Nutritional Intervention and a Personalized Graded Activity Functional Training Program on Physical Performance in Hospitalized Older Patients, Compared to Usual Care: A Randomized Clinical Trial

Run by Radboud University Medical Center · NCT05413616 · Data updated 2026-11-12

This study is testing if personalized nutrition and exercise can help older patients in the hospital improve their physical performance and stay active after they go home.

Quick facts

Study typeInterventional
Ages65 Years and up
SexAll
Enrollment136 (estimated)
SponsorRadboud University Medical Center
Academic / other
Locations1 site (Nijmegen, Gelderland)
StatusRecruiting
StartedJuly 4, 2022
Main results expectedNovember 1, 2026
Study endsJuly 1, 2027
Registry record updatedJuly 24, 2025
Trial IDNCT05413616 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals aged 65 and older who are admitted to a clinical ward in the Nijmegen area.

Probably not a fit

Patients who are completely reliant on tube feeding or have severe renal insufficiency may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to enhance physical performance in older patients by implementing a personalized nutritional intervention alongside a graded activity functional training program. The intervention begins upon hospital admission and continues post-discharge in a home care setting, supported by an e-health application. The study focuses on addressing the risks of muscle mass decline and decreased physical functioning in hospitalized older adults, which can negatively impact their independence and quality of life. By combining tailored nutrition and exercise, the study seeks to improve outcomes for this vulnerable population.

Why it matters

Potential benefit: If successful, this approach could significantly enhance the physical health and independence of older patients after hospitalization.

How similar studies have gone: While similar interventions have shown success in healthy individuals and athletes, this approach has not been extensively tested in older hospitalized patients, making it a novel exploration.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Aged ≥65 years
* Living within the Nijmegen area (within 40km)
* Admitted to clinical ward of Radboudumc or CWZ
* Understanding and speaking of the Dutch language
* Mentally competent
* Signed informed consent

Exclusion Criteria:

* Complete use of tube feeding or parenteral nutrition
* Renal insufficiency (MDRD-GFR \< 30ml/min)

Where it's running

  • Sabien van Exter
    Nijmegen, Gelderland, Netherlands
    Recruiting

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.