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Clinical trial No longer in our active list Interventional Ages 18 and up

Improving pain relief after knee replacement surgery with additional nerve blocks

Official title: Evaluation of the Analgesic Benefit of Adding the Blocks of the Intermediate and Medial Femoral Cutaneous Nerves in Addition to the Femoral Triangle Block for Postoperative Analgesia After a Knee Replacement Surgery: A Randomized Controlled Clinical Trial

Run by Centre hospitalier de l'Université de Montréal (CHUM) · NCT06038851 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is testing if adding extra nerve blocks to the usual pain relief method after knee replacement surgery can help patients feel less pain and recover faster.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment122 (estimated)
SponsorCentre hospitalier de l'Université de Montréal (CHUM)
Academic / other
Locations1 site (Montreal, Quebec)
Trial IDNCT06038851 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and over who are scheduled for primary total knee arthroplasty and classified as ASA 1 to 3.

Probably not a fit

Patients who may not benefit include those with chronic pain requiring high doses of opioids, contraindications to nerve blocks, or those unable to communicate effectively with the healthcare team.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of adding intermediate and medial femoral cutaneous nerve blocks to the standard femoral triangle block for postoperative pain management in patients undergoing total knee replacement surgery. The aim is to enhance analgesia and facilitate early mobilization, which is crucial for recovery. By utilizing a multimodal approach to pain relief, the study seeks to determine if this combined nerve block technique can provide better outcomes compared to traditional methods. The research will involve a randomized controlled design to assess the analgesic benefits in the target population.

Why it matters

Potential benefit: If successful, this approach could significantly improve pain management and recovery times for patients after knee replacement surgery.

How similar studies have gone: While some preliminary studies have explored similar nerve block techniques, this specific approach has not been extensively tested in a randomized controlled setting.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* 18 years and over, requiring a primary total knee arthroplasty
* 'American Society of Anesthesiologists' classification 1 to 3

Exclusion Criteria:

* Refusal or unable to consent
* Contraindications to a peripheral nerve block;
* Inability to communicate with the healthcare team or the research team;
* Inability to understand follow-up instructions or questionnaires;
* Chronic pain requiring the intake of the equivalent of more than 60 mg of morphine daily;
* Pregnancy;
* Patients weighing less than 50 kg (to limit the risk of intoxication with local anesthetics).

Where it's running

  • Centre Hospitalier de l'Université de Montréal (CHUM)
    Montreal, Quebec, Canada     Recruiting

Study contacts

  • Principal investigator: Maxim Roy, MD, FRCPC — Centre hospitalier de l'Université de Montréal (CHUM)
  • Study coordinator: Maxim Roy, MD, FRCPC
  • Email: maxim.roy20@gmail.com
  • Phone: 514-890-8000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Post Operative Pain 71Anesthesia, Local 11Centre hospitalier de l'Université de Montréal (CHUM) 72
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.