Improving lung function in critically ill patients on mechanical ventilation
An Observational Study of the Relationship Between Pressure-volume Curves and Recruitability of the Lung in Mechanically Ventilated Critically Ill Patients With Respiratory Failure
This study is testing if a procedure that helps inflate the lungs can improve breathing and recovery for critically ill patients on mechanical ventilation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | University of Oxford Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Reading) |
| Trial ID | NCT05508724 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on critically ill patients who are receiving mechanical ventilation due to respiratory failure. It aims to evaluate the effectiveness of recruitment manoeuvres, a procedure used to inflate the lungs and open collapsed areas, thereby improving oxygenation and preventing further lung injury. The study will monitor the changes in lung and heart function during and after these manoeuvres to better understand their impact on patient recovery. By analyzing these effects, the research seeks to enhance treatment protocols in intensive care settings.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are receiving mechanical ventilation for respiratory failure in an ICU setting.
Not a fit: Patients who are receiving palliative care or have language barriers that prevent informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved recovery outcomes for patients with respiratory failure requiring mechanical ventilation.
How similar studies have performed: Previous studies have shown that recruitment manoeuvres can improve lung function in mechanically ventilated patients, suggesting that this approach has potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male and female, aged 18 years or above * Receiving mechanical ventilation for respiratory failure via an endotracheal tube on ICU Exclusion Criteria: * Consultee indicates patient would be likely to decline enrolment * Patient is receiving palliative care * Language barriers prevent sufficiently good communication with patient or consultee for full consent to be obtained
Where this trial is running
Reading
- Royal Berkshire Hospital, Royal Berkshire Foundation Trust — Reading, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Jessica S Luiz, MBBS MRes
- Email: jessica.luiz@dpag.ox.ac.uk
- Phone: +44 01865272117
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.