Improving heart health through nutrition for childhood cancer survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Cardiovascular Health Equity Through Food (CHEF) program aims to support healthy eating habits among childhood cancer survivors to promote long-term cardiovascular health. This proof-of-concept study will assess the impact of the CHEF intervention on cardiovascular outcomes by collecting data through surveys, interviews, and medical records. Participants will be screened for eligibility and will engage in questionnaires and interviews over a six-month period. The study seeks to identify effective strategies for implementing the intervention in this vulnerable population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Child with any primary cancer diagnosis (non-relapsed, non-secondary malignancy) who has received cancer-directed therapy that includes chemotherapy and/or radiation therapy;
* Child is within one of the following time windows:

  1. Among those receiving chemotherapy, any time from start of last planned cycle of chemotherapy until 12 months from completion of chemotherapy;
  2. Among those receiving radiation therapy alone or radiation and surgery, any time from completion of radiation until 12 months post completion;
* Child has 1 or more cardiovascular risk factor (defined as any of: body mass index ≥ 85th percentile; systolic or diastolic blood pressure ≥90th percentile; dyslipidemia \[triglycerides ≥150 mg/dL, total cholesterol ≥200 mg/dL, LDL cholesterol ≥130 mg/dL, HDL cholesterol ≤40 mg/dL\]; impaired glucose metabolism \[fasting glucose ≥100 mg/dL, hemoglobin A1c ≥5.7%\]; anthracycline exposure ≥100 mg/m2; or any radiation exposure to chest, brain, thoracic spine, or total body);
* Child is ≤18 years of age at time of enrollment, or over 18 years of age but under medical guardianship;
* Parent/guardian screened positive for food insecurity.\* \*Assessed through validated 2-item food insecurity screen.

Exclusion Criteria:

* Patient received only surgery, or watchful waiting/surveillance, for cancer- directed therapy;
* Foreign national family receiving cancer care as an embassy-pay patient.

Where it's running

• Boston Children's Hospital
  Boston, Massachusetts, United States Recruiting
• Dana-Farber Cancer Institute
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Rahela Aziz-Bose, MD — Dana-Farber Cancer Institute
• Study coordinator: Rahela Aziz-Bose, MD
• Email: rahela_aziz-bose@dfci.harvard.edu
• Phone: 617-632-3352

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.