Improving heart function in patients with LVAD support

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the potential recovery of heart function in patients with end-stage heart failure who are supported by a Left Ventricular Assist Device (LVAD). It employs a myocardial conditioning protocol that gradually reduces LVAD speed to increase the workload on the heart, potentially improving its function. The study aims to explore how this approach can reverse chronic left ventricular remodeling and enhance the quality of life for these patients. Previous studies suggest that such interventions may lead to significant improvements in heart function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with heart failure undergoing LVAD implantation as a bridge to transplant
* Enrolled in the Effects of Mechanical Unloading on Myocardial Function and Structure study (IRB 30622)

Exclusion Criteria:

* Neither the subject nor the subject's representative is willing to provide written consent for participation
* Subjects with adverse events leading to hospitalization during the optimum unloading phase are excluded from participation in the controlled reloading phase

Where it's running

• University of Utah
  Salt Lake City, Utah, United States Recruiting

Study contacts

• Principal investigator: Stavros Drakos, MD — University of Utah
• Study coordinator: John Kirk
• Email: john.kirk@hsc.utah.edu
• Phone: 801-585-2944

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Voice-based detection of heart failure deterioration using Noah Labs Vox

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.