Improving executive function in young people with 22q11.2 deletion syndrome using brain stimulation
Official title: Using Transcranial Alternating Current Stimulation With Starstim Home Device to Improve Executive Function in Youths With 22q11.2 Deletion Syndrome: A Randomized Double-blind Sham-controlled Study
Run by University of Geneva, Switzerland · NCT05664412 · Data updated 2026-11-12
This study is testing if a type of brain stimulation can help improve memory and thinking skills in children and young adults with 22q11.2 deletion syndrome.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 14 Years to 25 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | University of Geneva, Switzerland Academic / other |
| Locations | 1 site (Geneva, Canton of Geneva) |
| Status | Recruiting |
| Started | October 20, 2023 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | December 2, 2025 |
| Trial ID | NCT05664412 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 14 to 25 with a confirmed genetic diagnosis of 22q11.2 deletion syndrome.
✕Probably not a fit
Patients with epilepsy, deep brain stimulation electrodes, traumatic brain injury, or facial metal implants may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project investigates the effects of transcranial alternating current stimulation (tACS) on cognitive function in children, adolescents, and young adults with 22q11.2 deletion syndrome. The study aims to enhance visual working memory performance through a non-invasive brain stimulation protocol tailored to individual participants. By targeting cognitive deficits early, the research seeks to mitigate the risk of developing psychotic symptoms later in life. Participants will receive at-home tACS treatments using the Starstim-Home device, allowing for personalized intervention based on their specific needs.
Why it matters
Potential benefit: If successful, this intervention could improve cognitive function and potentially delay or prevent the onset of psychotic symptoms in individuals with 22q11.2 deletion syndrome.
How similar studies have gone: While the approach of using tACS for cognitive enhancement is relatively novel, similar studies have shown promise in improving cognitive functions in other populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Confirmed genetic diagnosis of 22q11DS * Age between 14 and 25 years old * Willingness to participate * Informed Consent signed by the subject and/or the caregiver(s) Exclusion Criteria: * Epilepsy * Deep brain stimulation electrodes * Traumatic brain injury * Facial metal implants
Where it's running
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University of Geneva
Geneva, Canton of Geneva, Switzerland Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.